Assessment of pituitary response to nasal application of synthetic gonadotropin releasing hormone in men

G. Potashnik; N. Ben Adereth; B. Lunenfeld; C. Rofe

doi:10.1016/s0015-0282(16)42617-8

Assessment of pituitary response to nasal application of synthetic gonadotropin releasing hormone in men

G. Potashnik, N. Ben Adereth, B. Lunenfeld, C. Rofe

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

An attempt has been made to assess the pituitary response to the nasal application of synthetic gonadotropin-releasing hormone (GnRH) in three oligospermic and two azoospermic men. Intranasal administration of 3 mg of GnRH in aqueous or natural plant gum solution produced a pituitary response pattern similar to that produced by the intramuscular injection of 100 μg, with respect to plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). No technical difficulties or side effects were observed. GnRH in a nasal drop preparation seems to be effective in releasing LH and FSH in men. These findings may have a practical application in those cases where longterm therapy with the hormone is indicated.

Original language	English
Pages (from-to)	650-654
Number of pages	5
Journal	Fertility and Sterility
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/s0015-0282(16)42617-8
State	Published - 1 Jan 1977

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

Access to Document

10.1016/s0015-0282(16)42617-8

Cite this

@article{29443281d86f4eaca560f93c1aa427ce,

title = "Assessment of pituitary response to nasal application of synthetic gonadotropin releasing hormone in men",

abstract = "An attempt has been made to assess the pituitary response to the nasal application of synthetic gonadotropin-releasing hormone (GnRH) in three oligospermic and two azoospermic men. Intranasal administration of 3 mg of GnRH in aqueous or natural plant gum solution produced a pituitary response pattern similar to that produced by the intramuscular injection of 100 μg, with respect to plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). No technical difficulties or side effects were observed. GnRH in a nasal drop preparation seems to be effective in releasing LH and FSH in men. These findings may have a practical application in those cases where longterm therapy with the hormone is indicated.",

author = "G. Potashnik and {Ben Adereth}, N. and B. Lunenfeld and C. Rofe",

note = "Funding Information: This investigation was supported by grants from the Swedish Medical Research Council (grant 2028) and the WHO Expanded Programme of Research, Development and Research Training. The authors thank Ms. L.M. Lindeholm for her assistance in the preparation of the manusc_ript.",

year = "1977",

month = jan,

day = "1",

doi = "10.1016/s0015-0282(16)42617-8",

language = "English",

volume = "28",

pages = "650--654",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Assessment of pituitary response to nasal application of synthetic gonadotropin releasing hormone in men

AU - Potashnik, G.

AU - Ben Adereth, N.

AU - Lunenfeld, B.

AU - Rofe, C.

N1 - Funding Information: This investigation was supported by grants from the Swedish Medical Research Council (grant 2028) and the WHO Expanded Programme of Research, Development and Research Training. The authors thank Ms. L.M. Lindeholm for her assistance in the preparation of the manusc_ript.

PY - 1977/1/1

Y1 - 1977/1/1

N2 - An attempt has been made to assess the pituitary response to the nasal application of synthetic gonadotropin-releasing hormone (GnRH) in three oligospermic and two azoospermic men. Intranasal administration of 3 mg of GnRH in aqueous or natural plant gum solution produced a pituitary response pattern similar to that produced by the intramuscular injection of 100 μg, with respect to plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). No technical difficulties or side effects were observed. GnRH in a nasal drop preparation seems to be effective in releasing LH and FSH in men. These findings may have a practical application in those cases where longterm therapy with the hormone is indicated.

AB - An attempt has been made to assess the pituitary response to the nasal application of synthetic gonadotropin-releasing hormone (GnRH) in three oligospermic and two azoospermic men. Intranasal administration of 3 mg of GnRH in aqueous or natural plant gum solution produced a pituitary response pattern similar to that produced by the intramuscular injection of 100 μg, with respect to plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). No technical difficulties or side effects were observed. GnRH in a nasal drop preparation seems to be effective in releasing LH and FSH in men. These findings may have a practical application in those cases where longterm therapy with the hormone is indicated.

UR - http://www.scopus.com/inward/record.url?scp=0017711984&partnerID=8YFLogxK

U2 - 10.1016/s0015-0282(16)42617-8

DO - 10.1016/s0015-0282(16)42617-8

M3 - Article

AN - SCOPUS:0017711984

SN - 0015-0282

VL - 28

SP - 650

EP - 654

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 6

ER -

Assessment of pituitary response to nasal application of synthetic gonadotropin releasing hormone in men

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this