Association between Mode of Delivery of the Breech Fetus and Hospitalizations Due to Inflammatory Bowel Disease during Childhood

Omri Zamstein, Ahinoam Glusman Bendersky, Eyal Sheiner, Daniella Landau, Amalia Levy

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Goals: While evidence suggests short-term benefits in neonatal morbidity and mortality from cesarean delivery of the fetus in breech presentation, the long-term implications for the offspring are less clear. To assess the implications of the mode of delivery on offspring's health, we have evaluated the long-term gastrointestinal (GI) morbidity of offspring with a breech presentation delivered in either way. Materials and Methods: A population-based retrospective cohort study including singleton deliveries in breech presentation occurring between 1991 and 2014 at a tertiary referral hospital. Incidence of hospitalizations of the offspring up to the age of 18 years involving GI morbidity was compared between those delivered via cesarean section or vaginally. A Kaplan-Meier survival curve compared cumulative GI morbidity. A Weibull parametric survival model controlled for confounders while accounting for repeated occurrence of mothers and dependence among siblings. Results: Overall, 86.9% (n=6376) of the 7337 fetuses in breech presentation, were delivered abdominally. Hospitalizations involving GI morbidity were higher in offspring delivered by cesarean section, specifically due to inflammatory bowel disease (IBD). Kaplan-Meier survival curve revealed the higher cumulative incidence of total GI morbidity and IBD specifically in the cesarean delivery group (P<0.001 and P=0.004, respectively). Using a Weibull parametric while controlling for relevant confounders, cesarean delivery emerged as an independent risk factor for long-term IBD-related morbidity of the offspring delivered in breech presentation (adjusted hazard ratio=3.18, 95% confidence interval: 1.47-6.87, P=0.003). Conclusion: Cesarean delivery is associated with higher rates of hospitalizations due to IBD and total GI morbidity during childhood in term singleton in breech presentation.

Original languageEnglish
Pages (from-to)E161-E165
JournalJournal of Clinical Gastroenterology
Volume56
Issue number2
DOIs
StatePublished - 1 Feb 2022

Keywords

  • breech presentation
  • cesarean delivery
  • inflammatory bowel disease

ASJC Scopus subject areas

  • Gastroenterology

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