Association between prenatal exposure to metals and neonatal morbidity

Isabella Karakis; Batia Sarov; Daniella Landau; Esther Manor; Maayan Yitshak-Sade; Michal Rotenberg; Reli Hershkovitz; Itamar Grotto; Elena Gurevich; Lena Novack

doi:10.1080/15287394.2014.932313

Association between prenatal exposure to metals and neonatal morbidity

Isabella Karakis, Batia Sarov, Daniella Landau, Esther Manor, Maayan Yitshak-Sade, Michal Rotenberg, Reli Hershkovitz, Itamar Grotto, Elena Gurevich, Lena Novack

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17 Scopus citations

Abstract

An association between prenatal exposure to (semi-)metals and of neonatal morbidity was assessed by introducing an oxidative stress as a possible intermediate step. An oxidative stress was measured by cell proliferation (CP) ratio in umbilical cord blood cells. Urine samples of 18 out of 58 enrolled women (31%) were positive for (semi-)metals; 25.9% of women were positive for aluminum (Al). The CP ratio was higher (1) in subjects with Al, (2) in mothers to newborns diagnosed as small-for-gestational age (p value =.052), (3) neonates that weighed less (p value =.079), and (4) in women who experienced repeated abortions (p value =.049). Our findings suggest the possibility of metal-induced oxidative stress.

Original language	English
Pages (from-to)	1281-1284
Number of pages	4
Journal	Journal of Toxicology and Environmental Health - Part A: Current Issues
Volume	77
Issue number	21
DOIs	https://doi.org/10.1080/15287394.2014.932313
State	Published - 26 Nov 2014

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/15287394.2014.932313

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abstract = "An association between prenatal exposure to (semi-)metals and of neonatal morbidity was assessed by introducing an oxidative stress as a possible intermediate step. An oxidative stress was measured by cell proliferation (CP) ratio in umbilical cord blood cells. Urine samples of 18 out of 58 enrolled women (31%) were positive for (semi-)metals; 25.9% of women were positive for aluminum (Al). The CP ratio was higher (1) in subjects with Al, (2) in mothers to newborns diagnosed as small-for-gestational age (p value =.052), (3) neonates that weighed less (p value =.079), and (4) in women who experienced repeated abortions (p value =.049). Our findings suggest the possibility of metal-induced oxidative stress.",

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AU - Karakis, Isabella

AU - Sarov, Batia

AU - Landau, Daniella

AU - Manor, Esther

AU - Yitshak-Sade, Maayan

AU - Rotenberg, Michal

AU - Hershkovitz, Reli

AU - Grotto, Itamar

AU - Gurevich, Elena

AU - Novack, Lena

PY - 2014/11/26

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AB - An association between prenatal exposure to (semi-)metals and of neonatal morbidity was assessed by introducing an oxidative stress as a possible intermediate step. An oxidative stress was measured by cell proliferation (CP) ratio in umbilical cord blood cells. Urine samples of 18 out of 58 enrolled women (31%) were positive for (semi-)metals; 25.9% of women were positive for aluminum (Al). The CP ratio was higher (1) in subjects with Al, (2) in mothers to newborns diagnosed as small-for-gestational age (p value =.052), (3) neonates that weighed less (p value =.079), and (4) in women who experienced repeated abortions (p value =.049). Our findings suggest the possibility of metal-induced oxidative stress.

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Association between prenatal exposure to metals and neonatal morbidity

Abstract

ASJC Scopus subject areas

UN SDGs

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