Association of cerebral activity with MRI scans in infants with neonatal encephalopathy undergoing therapeutic hypothermia

Eilon Shany, Nasrin Taha, Ela Benkovich, Rosa Novoa, Irina Meledin, Amarilla Mandola, Victor Novack, Ilan Shelef

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations

    Abstract

    We aimed to correlate amplitude-integrated EEG (aEEG) in neonatal hypoxic ischemic encephalopathy (HIE) with early magnetic resonance imaging (MRI). In this retrospective study, 32 neonates over 35 weeks’ gestation with moderate/severe HIE who were treated with hypothermia were included. Early MRI scans and daily aEEG background were categorized to mild/normal, moderate, and severely abnormal. Time to sleep cycling was noted on aEEG. Mantel-Haenszel test for trends was used to explore associations between aEEG and MRI and outcome. LOESS regression was used for exploring the association of cycling with MRI scores. MRI was normal/mildly abnormal in 20 (63%) infants; in 9 (28%), moderately abnormal; and in 3 (9%), severely abnormal. Twenty-seven (84%) infants s urvived. MRI severity score was significantly associated with aEEG background score on the third and fourth days of life (p < 0.01). An increase in the MRI severity score was noted if sleep cycling appeared after the fifth day of life. Conclusions: Depressed aEEG at the third and fourth days of life and appearance of cycling beyond the fifth day of life are associated with cerebral MRI abnormalities and may be associated with increased risk of abnormal outcome.

    Original languageEnglish
    Pages (from-to)851-861
    Number of pages11
    JournalEuropean Journal of Pediatrics
    Volume178
    Issue number6
    DOIs
    StatePublished - 1 Jun 2019

    Keywords

    • Brain imaging
    • Neonate
    • Outcome
    • aEEG

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health

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