TY - JOUR
T1 - Association of Osteoarthritis and Functional Limitations With Cognitive Impairment Among Older Adults in the United States
AU - Rakutt, Maxwell J.
AU - Mace, Ryan A.
AU - Conley, Caitlin E.W.
AU - Stone, Austin V.
AU - Duncan, Stephen T.
AU - Greenberg, Jonathan
AU - Landy, David C.
AU - Vranceanu, Ana Maria
AU - Jacobs, Cale A.
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023/10/1
Y1 - 2023/10/1
N2 - Objective: Given overlapping pathophysiology, this study sought to assess the association between osteoarthritis (OA), functional impairment, and cognitive impairment in the aging population. Methods: The National Health and Nutrition Examination Survey was used to identify participants >60 years of age. We analyzed multivariable associations of grouped participants that underwent cognitive function testing using linear and logistic regression, adjusting for sex, age, race, and ethnicity. Results: Of 2776 identified participants representing a population of 50,242,917, 40% did not report OA or functional limitations; 21% had OA but not functional limitations; 15% did not have OA but had functional limitations; 17% had OA and related functional limitations; and 7% had OA and non-arthritic functional limitations. OA was not independently associated with cognitive impairment. Contrarily, functional limitations were associated with cognitive impairment regardless of OA diagnosis. Discussion: Cognitive impairment is not associated with OA, but rather functional limitations, potentially guiding future intervention.
AB - Objective: Given overlapping pathophysiology, this study sought to assess the association between osteoarthritis (OA), functional impairment, and cognitive impairment in the aging population. Methods: The National Health and Nutrition Examination Survey was used to identify participants >60 years of age. We analyzed multivariable associations of grouped participants that underwent cognitive function testing using linear and logistic regression, adjusting for sex, age, race, and ethnicity. Results: Of 2776 identified participants representing a population of 50,242,917, 40% did not report OA or functional limitations; 21% had OA but not functional limitations; 15% did not have OA but had functional limitations; 17% had OA and related functional limitations; and 7% had OA and non-arthritic functional limitations. OA was not independently associated with cognitive impairment. Contrarily, functional limitations were associated with cognitive impairment regardless of OA diagnosis. Discussion: Cognitive impairment is not associated with OA, but rather functional limitations, potentially guiding future intervention.
KW - aging
KW - cognitive impairment
KW - dementia
KW - functional limitations
KW - osteoarthritis
UR - https://www.scopus.com/pages/publications/85147380727
U2 - 10.1177/08982643231153459
DO - 10.1177/08982643231153459
M3 - Article
C2 - 36680455
AN - SCOPUS:85147380727
SN - 0898-2643
VL - 35
SP - 643
EP - 650
JO - Journal of Aging and Health
JF - Journal of Aging and Health
IS - 9
ER -