TY - JOUR
T1 - Association of the Epstein-Barr virus with Hodgkin's disease in Southern Israel
AU - Benharroch, Daniel
AU - Brousset, Pierre
AU - Goldstein, Jed
AU - Prinsloo, Isebrand
AU - Rabinovitch, Daniella
AU - Shendler, Yaakov
AU - Ariad, Samuel
AU - Levy, Amalia
AU - Delsol, Georges
AU - Gopas, Jacob
PY - 1997/6/27
Y1 - 1997/6/27
N2 - Epstein-Barr virus (EBV) has been frequently documented in the putative neoplastic Hodgkin-Reed-Sternberg (HRS) cells, in lymph nodes from patients with Hodgkin's disease (HD). This association varies in different geographic areas and between industrialized and developing countries, as does the epidemiological pattern of the disease. In the present study of 106 cases of HD from the Soroka Medical Center in Beer-Sheva, which serves as the only hospital for most of the southern part of Israel, we found an association with EBV expression in only 30% of the patients; 45% of mixed cellularity (MC) cases compared with 21% of nodular sclerosis (NS) cases were positive for EBV. The number of patients in the 0- 14-year-old age group was limited; however, 8 of these 11 children were EBV sequences is probably related to the small number of children in our series. A low proportion of EBV-associated disease in older adults may be contributory. Other factors may be involved.
AB - Epstein-Barr virus (EBV) has been frequently documented in the putative neoplastic Hodgkin-Reed-Sternberg (HRS) cells, in lymph nodes from patients with Hodgkin's disease (HD). This association varies in different geographic areas and between industrialized and developing countries, as does the epidemiological pattern of the disease. In the present study of 106 cases of HD from the Soroka Medical Center in Beer-Sheva, which serves as the only hospital for most of the southern part of Israel, we found an association with EBV expression in only 30% of the patients; 45% of mixed cellularity (MC) cases compared with 21% of nodular sclerosis (NS) cases were positive for EBV. The number of patients in the 0- 14-year-old age group was limited; however, 8 of these 11 children were EBV sequences is probably related to the small number of children in our series. A low proportion of EBV-associated disease in older adults may be contributory. Other factors may be involved.
UR - http://www.scopus.com/inward/record.url?scp=0030916412&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0215(19970410)71:2<138::AID-IJC2>3.0.CO;2-1
DO - 10.1002/(SICI)1097-0215(19970410)71:2<138::AID-IJC2>3.0.CO;2-1
M3 - Article
AN - SCOPUS:0030916412
SN - 0020-7136
VL - 71
SP - 138
EP - 141
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 2
ER -
