Association of the Epstein-Barr virus with Hodgkin's disease in Southern Israel

Daniel Benharroch, Pierre Brousset, Jed Goldstein, Isebrand Prinsloo, Daniella Rabinovitch, Yaakov Shendler, Samuel Ariad, Amalia Levy, Georges Delsol, Jacob Gopas

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Epstein-Barr virus (EBV) has been frequently documented in the putative neoplastic Hodgkin-Reed-Sternberg (HRS) cells, in lymph nodes from patients with Hodgkin's disease (HD). This association varies in different geographic areas and between industrialized and developing countries, as does the epidemiological pattern of the disease. In the present study of 106 cases of HD from the Soroka Medical Center in Beer-Sheva, which serves as the only hospital for most of the southern part of Israel, we found an association with EBV expression in only 30% of the patients; 45% of mixed cellularity (MC) cases compared with 21% of nodular sclerosis (NS) cases were positive for EBV. The number of patients in the 0- 14-year-old age group was limited; however, 8 of these 11 children were EBV sequences is probably related to the small number of children in our series. A low proportion of EBV-associated disease in older adults may be contributory. Other factors may be involved.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalInternational Journal of Cancer
Issue number2
StatePublished - 27 Jun 1997

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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