Associations between daily-living physical activity and laboratory-based assessments of motor severity in patients with falls and Parkinson's disease

Irina Galperin, Inbar Hillel, Silvia Del Din, Esther M.J. Bekkers, Alice Nieuwboer, Giovanni Abbruzzese, Laura Avanzino, Freek Nieuwhof, Bastiaan R. Bloem, Lynn Rochester, Ugo Della Croce, Andrea Cereatti, Nir Giladi, Anat Mirelman, Jeffrey M. Hausdorff

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Introduction: Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g., MDS-UPDRS part III), laboratory-based measures of gait and balance, and daily-living physical activity measures in patients with PD. Methods: Data from 125 patients (age: 71.7 ± 6.5 years, Hoehn and Yahr: 1–3, 60.5% men) were analyzed. The MDS-UPDRS-part III was used as the gold standard of motor symptom severity. Gait and balance were quantified in the laboratory. Daily-living gait and physical activity metrics were extracted from an accelerometer worn on the lower back for 7 days. Results: In multivariate analyses, daily-living physical activity and gait metrics, laboratory-based balance, demographics and subject characteristics together explained 46% of the variance in MDS-UPDRS-part III scores. Daily-living measures accounted for 62% of the explained variance, laboratory measures 30%, and demographics and subject characteristics 7% of the explained variance. Conversely, demographics and subject characteristics, laboratory-based measures of gait symmetry, and motor symptom severity together explained less than 30% of the variance in total daily-living physical activity. MDS-UPDRS-part III scores accounted for 13% of the explained variance, i.e., <4% of all the variance in total daily-living activity. Conclusions: Our findings suggest that conventional measures of motor symptom severity do not strongly reflect daily-living activity and that daily-living measures apparently provide important information that is not captured in a conventional one-time, laboratory assessment of gait, balance or the MDS-UPDRS. To provide a more complete evaluation, wearable devices should be considered.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalParkinsonism and Related Disorders
StatePublished - 1 May 2019
Externally publishedYes


  • Accelerometers
  • Daily-living activity
  • Digital health
  • Inertial measurement units
  • Parkinson's disease
  • Wearable device

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


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