TY - JOUR
T1 - Associations between early-life exposure to PM2.5and reductions in childhood lung function in two North American longitudinal pregnancy cohort studies
AU - Rosa, Maria José
AU - Lamadrid-Figueroa, Hector
AU - Alcala, Cecilia
AU - Colicino, Elena
AU - Tamayo-Ortiz, Marcela
AU - Mercado-Garcia, Adriana
AU - Kloog, Itai
AU - Just, Allan C.
AU - Bush, Douglas
AU - Carroll, Kecia N.
AU - Téllez-Rojo, Martha María
AU - Wright, Robert O.
AU - Gennings, Chris
AU - Wright, Rosalind J.
N1 - Funding Information:
The PROGRESS study was supported by the National Institute of Environmental Health Sciences grants R00ES027496, R01ES014930, R01ES013744, R24ES028522, P30ES023515, R01ES021357, R01ES034521, and R01ES032242. The ACCESS study was supported by National Institutes of Health grants R01ES010932, U01HL072494, R01MD006086, R01HL080674, UG3OD023337. Biostatistics methods development was funded by U54TR004213. We also thank the ABC (American British Cowdray Medical Center) in Mexico for providing some of the needed research facilities.
Publisher Copyright:
© 2023 Wolters Kluwer Health. All rights reserved.
PY - 2023/2/14
Y1 - 2023/2/14
N2 - Background: Data integration of epidemiologic studies across different geographic regions can provide enhanced exposure contrast and statistical power to examine adverse respiratory effects of early-life exposure to particulate matter <2.5 microns in diameter (PM2.5). Methodological tools improve our ability to combine data while more fully accounting for study heterogeneity. Methods: Analyses included children enrolled in two longitudinal birth cohorts in Boston, Massachusetts, and Mexico City. Propensity score matching using the 1:3 nearest neighbor with caliper method was used. Residential PM2.5exposure was estimated from 2 months before birth to age 6 years using a validated satellite-based spatiotemporal model. Lung function was tested at ages 6-11 years and age, height, race, and sex adjusted z scores were estimated for FEV1, FVC, FEF25-75%, and FEV1/FVC. Using distributed lag nonlinear models, we examined associations between monthly averaged PM2.5levels and lung function outcomes adjusted for covariates, in unmatched and matched pooled samples. Results: In the matched pooled sample, PM2.5exposure between postnatal months 35-44 and 35-52 was associated with lower FEV1and FVC z scores, respectively. A 5 µg/m3increase in PM2.5was associated with a reduction in FEV1z score of 0.13 (95% CI = -0.26, -0.01) and a reduction in FVC z score of 0.13 (95% CI = -0.25, -0.01). Additionally PM2.5during postnatal months 23-39 was associated with a reduction in FEF25-75%z score of 0.31 (95% CI = -0.57, -0.05). Conclusions: Methodological tools enhanced our ability to combine multisite data while accounting for study heterogeneity. Ambient PM2.5exposure in early childhood was associated with lung function reductions in middle childhood.
AB - Background: Data integration of epidemiologic studies across different geographic regions can provide enhanced exposure contrast and statistical power to examine adverse respiratory effects of early-life exposure to particulate matter <2.5 microns in diameter (PM2.5). Methodological tools improve our ability to combine data while more fully accounting for study heterogeneity. Methods: Analyses included children enrolled in two longitudinal birth cohorts in Boston, Massachusetts, and Mexico City. Propensity score matching using the 1:3 nearest neighbor with caliper method was used. Residential PM2.5exposure was estimated from 2 months before birth to age 6 years using a validated satellite-based spatiotemporal model. Lung function was tested at ages 6-11 years and age, height, race, and sex adjusted z scores were estimated for FEV1, FVC, FEF25-75%, and FEV1/FVC. Using distributed lag nonlinear models, we examined associations between monthly averaged PM2.5levels and lung function outcomes adjusted for covariates, in unmatched and matched pooled samples. Results: In the matched pooled sample, PM2.5exposure between postnatal months 35-44 and 35-52 was associated with lower FEV1and FVC z scores, respectively. A 5 µg/m3increase in PM2.5was associated with a reduction in FEV1z score of 0.13 (95% CI = -0.26, -0.01) and a reduction in FVC z score of 0.13 (95% CI = -0.25, -0.01). Additionally PM2.5during postnatal months 23-39 was associated with a reduction in FEF25-75%z score of 0.31 (95% CI = -0.57, -0.05). Conclusions: Methodological tools enhanced our ability to combine multisite data while accounting for study heterogeneity. Ambient PM2.5exposure in early childhood was associated with lung function reductions in middle childhood.
UR - http://www.scopus.com/inward/record.url?scp=85144125209&partnerID=8YFLogxK
U2 - 10.1097/EE9.0000000000000234
DO - 10.1097/EE9.0000000000000234
M3 - Article
C2 - 36777528
AN - SCOPUS:85144125209
SN - 2474-7882
VL - 7
SP - E234
JO - Environmental Epidemiology
JF - Environmental Epidemiology
IS - 1
ER -
