TY - JOUR
T1 - Atherosclerotic Plaque Erosion
T2 - Mechanisms, Clinical Implications, and Potential Therapeutic Strategies-A Review
AU - Bruoha, Sharon
AU - Galli, Mattia
AU - Sabouret, Pierre
AU - Yosefy, Chaim
AU - Taha, Louay
AU - Gragnano, Felice
AU - Savage, Michael P.
AU - Shuvy, Mony
AU - Biondi-Zoccai, Giuseppe
AU - Glikson, Michael
AU - Asher, Elad
N1 - Publisher Copyright:
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - ABSTRACT: Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. While rupture of vulnerable plaques has been extensively studied, a distinct mechanism known as plaque erosion (PE) has gained recognition and attention in recent years. PE, characterized by the loss of endothelial cell lining in the presence of intact fibrous cap, contributes to a significant and growing proportion of acute coronary events. However, despite a heterogeneous substrate underlying coronary thrombosis, treatment remains identical. This article provides an overview of atherosclerotic PE characteristics and its underlying mechanisms, highlights its clinical implications, and discusses potential therapeutic strategies.
AB - ABSTRACT: Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. While rupture of vulnerable plaques has been extensively studied, a distinct mechanism known as plaque erosion (PE) has gained recognition and attention in recent years. PE, characterized by the loss of endothelial cell lining in the presence of intact fibrous cap, contributes to a significant and growing proportion of acute coronary events. However, despite a heterogeneous substrate underlying coronary thrombosis, treatment remains identical. This article provides an overview of atherosclerotic PE characteristics and its underlying mechanisms, highlights its clinical implications, and discusses potential therapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=85195530281&partnerID=8YFLogxK
U2 - 10.1097/FJC.0000000000001554
DO - 10.1097/FJC.0000000000001554
M3 - Review article
C2 - 38421206
AN - SCOPUS:85195530281
SN - 0160-2446
VL - 83
SP - 547
EP - 556
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
IS - 6
ER -
