Attention deficit hyperactivity disorder symptoms in patients with cystic fibrosis

Malena Cohen-Cymberknoh, Tzlil Tanny, Oded Breuer, Hannah Blau, Huda Mussaffi, Diana Kadosh, Silvia Gartner, Alma Salinas, Lea Bentur, Vered Nir, Michal Gur, Joel Reiter, David Shoseyov, Eitan Kerem, Itai Berger

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: Cystic fibrosis (CF) is a chronic life-threatening disease. In patients who suffer from chronic disease, Attention Deficit Hyperactivity Disorder (ADHD) is associated with functional impairment that can affect adherence to treatment and consequently influence prognosis. Methods: CF patients filled in the ADHD Rating Scale (ADHD-RS) adapted to the DSM5 and were assessed on a continuous performance task (MOXO-CPT), a standardized-computerized test designed to evaluate several domains of attention. Results: Of the 175 patients (99 males), 18% presented ADHD symptoms, according to ADHD-RS; 16% in the younger group (< 18 years), and 18.9% in the adult group. The male to female ratio was 3:1 in children and 1:1 in adults. Conclusions: The occurrence of ADHD symptoms in patients with CF is substantially higher than in the general population and should be recognized as a co-morbidity of CF. As ADHD can impair adherence to therapy, further research is needed to investigate the effect of ADHD therapy on adherence.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalJournal of Cystic Fibrosis
Issue number2
StatePublished - 1 Mar 2018
Externally publishedYes


  • ADHD
  • Adherence
  • Chronic illness
  • Cystic fibrosis
  • Inflammatory disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


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