Attention deficit hyperactivity disorder symptoms in patients with cystic fibrosis

Malena Cohen-Cymberknoh; Tzlil Tanny; Oded Breuer; Hannah Blau; Huda Mussaffi; Diana Kadosh; Silvia Gartner; Alma Salinas; Lea Bentur; Vered Nir; Michal Gur; Joel Reiter; David Shoseyov; Eitan Kerem; Itai Berger

doi:10.1016/j.jcf.2017.11.020

Attention deficit hyperactivity disorder symptoms in patients with cystic fibrosis

Malena Cohen-Cymberknoh, Tzlil Tanny, Oded Breuer, Hannah Blau, Huda Mussaffi, Diana Kadosh, Silvia Gartner, Alma Salinas, Lea Bentur, Vered Nir, Michal Gur, Joel Reiter, David Shoseyov, Eitan Kerem, Itai Berger

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background: Cystic fibrosis (CF) is a chronic life-threatening disease. In patients who suffer from chronic disease, Attention Deficit Hyperactivity Disorder (ADHD) is associated with functional impairment that can affect adherence to treatment and consequently influence prognosis. Methods: CF patients filled in the ADHD Rating Scale (ADHD-RS) adapted to the DSM5 and were assessed on a continuous performance task (MOXO-CPT), a standardized-computerized test designed to evaluate several domains of attention. Results: Of the 175 patients (99 males), 18% presented ADHD symptoms, according to ADHD-RS; 16% in the younger group (< 18 years), and 18.9% in the adult group. The male to female ratio was 3:1 in children and 1:1 in adults. Conclusions: The occurrence of ADHD symptoms in patients with CF is substantially higher than in the general population and should be recognized as a co-morbidity of CF. As ADHD can impair adherence to therapy, further research is needed to investigate the effect of ADHD therapy on adherence.

Original language	English
Pages (from-to)	281-285
Number of pages	5
Journal	Journal of Cystic Fibrosis
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.jcf.2017.11.020
State	Published - 1 Mar 2018
Externally published	Yes

Keywords

ADHD
Adherence
Chronic illness
Cystic fibrosis
Inflammatory disease

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcf.2017.11.020

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title = "Attention deficit hyperactivity disorder symptoms in patients with cystic fibrosis",

abstract = "Background: Cystic fibrosis (CF) is a chronic life-threatening disease. In patients who suffer from chronic disease, Attention Deficit Hyperactivity Disorder (ADHD) is associated with functional impairment that can affect adherence to treatment and consequently influence prognosis. Methods: CF patients filled in the ADHD Rating Scale (ADHD-RS) adapted to the DSM5 and were assessed on a continuous performance task (MOXO-CPT), a standardized-computerized test designed to evaluate several domains of attention. Results: Of the 175 patients (99 males), 18% presented ADHD symptoms, according to ADHD-RS; 16% in the younger group (< 18 years), and 18.9% in the adult group. The male to female ratio was 3:1 in children and 1:1 in adults. Conclusions: The occurrence of ADHD symptoms in patients with CF is substantially higher than in the general population and should be recognized as a co-morbidity of CF. As ADHD can impair adherence to therapy, further research is needed to investigate the effect of ADHD therapy on adherence.",

keywords = "ADHD, Adherence, Chronic illness, Cystic fibrosis, Inflammatory disease",

author = "Malena Cohen-Cymberknoh and Tzlil Tanny and Oded Breuer and Hannah Blau and Huda Mussaffi and Diana Kadosh and Silvia Gartner and Alma Salinas and Lea Bentur and Vered Nir and Michal Gur and Joel Reiter and David Shoseyov and Eitan Kerem and Itai Berger",

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year = "2018",

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day = "1",

doi = "10.1016/j.jcf.2017.11.020",

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T1 - Attention deficit hyperactivity disorder symptoms in patients with cystic fibrosis

AU - Cohen-Cymberknoh, Malena

AU - Tanny, Tzlil

AU - Breuer, Oded

AU - Blau, Hannah

AU - Mussaffi, Huda

AU - Kadosh, Diana

AU - Gartner, Silvia

AU - Salinas, Alma

AU - Bentur, Lea

AU - Nir, Vered

AU - Gur, Michal

AU - Reiter, Joel

AU - Shoseyov, David

AU - Kerem, Eitan

AU - Berger, Itai

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Cystic fibrosis (CF) is a chronic life-threatening disease. In patients who suffer from chronic disease, Attention Deficit Hyperactivity Disorder (ADHD) is associated with functional impairment that can affect adherence to treatment and consequently influence prognosis. Methods: CF patients filled in the ADHD Rating Scale (ADHD-RS) adapted to the DSM5 and were assessed on a continuous performance task (MOXO-CPT), a standardized-computerized test designed to evaluate several domains of attention. Results: Of the 175 patients (99 males), 18% presented ADHD symptoms, according to ADHD-RS; 16% in the younger group (< 18 years), and 18.9% in the adult group. The male to female ratio was 3:1 in children and 1:1 in adults. Conclusions: The occurrence of ADHD symptoms in patients with CF is substantially higher than in the general population and should be recognized as a co-morbidity of CF. As ADHD can impair adherence to therapy, further research is needed to investigate the effect of ADHD therapy on adherence.

AB - Background: Cystic fibrosis (CF) is a chronic life-threatening disease. In patients who suffer from chronic disease, Attention Deficit Hyperactivity Disorder (ADHD) is associated with functional impairment that can affect adherence to treatment and consequently influence prognosis. Methods: CF patients filled in the ADHD Rating Scale (ADHD-RS) adapted to the DSM5 and were assessed on a continuous performance task (MOXO-CPT), a standardized-computerized test designed to evaluate several domains of attention. Results: Of the 175 patients (99 males), 18% presented ADHD symptoms, according to ADHD-RS; 16% in the younger group (< 18 years), and 18.9% in the adult group. The male to female ratio was 3:1 in children and 1:1 in adults. Conclusions: The occurrence of ADHD symptoms in patients with CF is substantially higher than in the general population and should be recognized as a co-morbidity of CF. As ADHD can impair adherence to therapy, further research is needed to investigate the effect of ADHD therapy on adherence.

KW - ADHD

KW - Adherence

KW - Chronic illness

KW - Cystic fibrosis

KW - Inflammatory disease

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DO - 10.1016/j.jcf.2017.11.020

M3 - Article

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SN - 1569-1993

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JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - 2

ER -

Attention deficit hyperactivity disorder symptoms in patients with cystic fibrosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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