Attenuated signaling associated with immune activation in HIV-1-infected individuals

Qibin Leng, Gadi Borkow, Zvi Bentwich

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Chronic immune activation is associated with impaired signal transduction. Since such activation is commonly found during HIV-1 infection, we studied cellular responses to non-specific T-cell receptor stimulation of PBMC obtained from 20 HIV-1 non-infected individuals and 23 highly or partially immune activated HIV-1 infected individuals. PBMC proliferation and ERK-1/2 phosphorylation following anti-CD3 stimulation, and constitutive levels of Cbl-b, were determined. Increased levels of Cbl-b, decreased proliferation, and lower ERK-1/2 phosphorylation were found in PBMC of highly immune activated HIV-1 infected individuals. The elevated expression of Cbl-b and impaired phosphorylation of ERK-1/2 associated with immune activation probably contribute to the attenuated proliferative and cellular responses characteristic of HIV-1 infection. Therefore, targeting immune negative modulators, such as Cbl-b, may serve as a novel approach for controlling HIV-1 disease progression.

Original languageEnglish
Pages (from-to)464-467
Number of pages4
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - 1 Jan 2002
Externally publishedYes


  • AIDS
  • Anti-CD3 stimulation
  • CTLA-4
  • Cbl-b
  • ERK
  • HIV-1
  • Immune activation
  • Proliferation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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