Aurintricarboxylic acid decreases proliferative potential of SKOV3 and MCF7 human carcinoma cells

V. Fraifeld, R. Seidman, O. Sagi, K. Muradian, M. Wolfson

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The effect of aurintricarboxylic acid (ATA) on cell growth and proliferative capacity was studied in human ovarian SKOV3 and breast MCF7 carcinoma cells. ATA moderately inhibited cell growth measured by a Neutral red assay after a 24-hour incubation of the cells in the presence of ATA. The ATA-treated cells displayed a markedly decreased capacity to proliferate, as was evident from a colony formation assay. The initial and delayed anti-proliferative effects of ATA were dose-dependent. Together, the results indicated that ATA offers the potential of being recognized as an anti-tumor drug, at least in certain types of cancers.

Original languageEnglish
Pages (from-to)1975-1978
Number of pages4
JournalAnticancer Research
Volume21
Issue number3 B
StatePublished - 20 Aug 2001

Keywords

  • Aurintricarboxylic acid
  • Cell growth
  • Colony formation
  • SKOV3 and MCF7 human carcinoma cells

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