Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

Tatiana V. Antipova; Kirill V. Zaitsev; Yuri F. Oprunenko; Alexander Ya. Zherebker; Gleb K. Rystsov; Marina Y. Zemskova; Valentina P. Zhelifonova; Natalya E. Ivanushkina; Anatoly G. Kozlovsky

doi:10.1016/j.bmcl.2019.126708

Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

Tatiana V. Antipova, Kirill V. Zaitsev, Yuri F. Oprunenko, Alexander Ya. Zherebker, Gleb K. Rystsov, Marina Y. Zemskova, Valentina P. Zhelifonova, Natalya E. Ivanushkina, Anatoly G. Kozlovsky

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Two new austalide meroterpenoids, named austalides V and W (1 and 2), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G), a structural fragment, first found in austalides. Austalides V (1) and W (2) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.

Original language	English
Article number	126708
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	29
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2019.126708
State	Published - 15 Nov 2019
Externally published	Yes

Keywords

AKT-mTORC1 signaling pathway
Aspergillus ustus
Austalide
Fungus
Prostate and bladder cancer cells

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2019.126708

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Antipova, T. V., Zaitsev, K. V., Oprunenko, Y. F., Ya. Zherebker, A., Rystsov, G. K., Zemskova, M. Y., Zhelifonova, V. P., Ivanushkina, N. E., & Kozlovsky, A. G. (2019). Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities. Bioorganic and Medicinal Chemistry Letters, 29(22), Article 126708. https://doi.org/10.1016/j.bmcl.2019.126708

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title = "Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities",

abstract = "Two new austalide meroterpenoids, named austalides V and W (1 and 2), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G), a structural fragment, first found in austalides. Austalides V (1) and W (2) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.",

keywords = "AKT-mTORC1 signaling pathway, Aspergillus ustus, Austalide, Fungus, Prostate and bladder cancer cells",

author = "Antipova, {Tatiana V.} and Zaitsev, {Kirill V.} and Oprunenko, {Yuri F.} and {Ya. Zherebker}, Alexander and Rystsov, {Gleb K.} and Zemskova, {Marina Y.} and Zhelifonova, {Valentina P.} and Ivanushkina, {Natalya E.} and Kozlovsky, {Anatoly G.}",

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year = "2019",

month = nov,

day = "15",

doi = "10.1016/j.bmcl.2019.126708",

language = "English",

volume = "29",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

AU - Antipova, Tatiana V.

AU - Zaitsev, Kirill V.

AU - Oprunenko, Yuri F.

AU - Ya. Zherebker, Alexander

AU - Rystsov, Gleb K.

AU - Zemskova, Marina Y.

AU - Zhelifonova, Valentina P.

AU - Ivanushkina, Natalya E.

AU - Kozlovsky, Anatoly G.

PY - 2019/11/15

Y1 - 2019/11/15

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AB - Two new austalide meroterpenoids, named austalides V and W (1 and 2), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G), a structural fragment, first found in austalides. Austalides V (1) and W (2) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.

KW - AKT-mTORC1 signaling pathway

KW - Aspergillus ustus

KW - Austalide

KW - Fungus

KW - Prostate and bladder cancer cells

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U2 - 10.1016/j.bmcl.2019.126708

DO - 10.1016/j.bmcl.2019.126708

M3 - Article

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AN - SCOPUS:85073055936

SN - 0960-894X

VL - 29

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

M1 - 126708

ER -

Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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