Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

Tatiana V. Antipova; Kirill V. Zaitsev; Yuri F. Oprunenko; Alexander Ya. Zherebker; Gleb K. Rystsov; Marina Y. Zemskova; Valentina P. Zhelifonova; Natalya E. Ivanushkina; Anatoly G. Kozlovsky

doi:10.1016/j.bmcl.2019.126708

Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

Tatiana V. Antipova
, Kirill V. Zaitsev
, Yuri F. Oprunenko
, Alexander Ya. Zherebker
, Gleb K. Rystsov
, Marina Y. Zemskova
, Valentina P. Zhelifonova
, Natalya E. Ivanushkina
, Anatoly G. Kozlovsky

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Two new austalide meroterpenoids, named austalides V and W (1 and 2), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G), a structural fragment, first found in austalides. Austalides V (1) and W (2) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.

Original language	English
Article number	126708
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	29
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2019.126708
State	Published - 15 Nov 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AKT-mTORC1 signaling pathway
Aspergillus ustus
Austalide
Fungus
Prostate and bladder cancer cells

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2019.126708

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Antipova, T. V., Zaitsev, K. V., Oprunenko, Y. F., Ya. Zherebker, A., Rystsov, G. K., Zemskova, M. Y., Zhelifonova, V. P., Ivanushkina, N. E., & Kozlovsky, A. G. (2019). Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities. Bioorganic and Medicinal Chemistry Letters, 29(22), Article 126708. https://doi.org/10.1016/j.bmcl.2019.126708

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title = "Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities",

abstract = "Two new austalide meroterpenoids, named austalides V and W (1 and 2), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G), a structural fragment, first found in austalides. Austalides V (1) and W (2) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.",

keywords = "AKT-mTORC1 signaling pathway, Aspergillus ustus, Austalide, Fungus, Prostate and bladder cancer cells",

author = "Antipova, \{Tatiana V.\} and Zaitsev, \{Kirill V.\} and Oprunenko, \{Yuri F.\} and \{Ya. Zherebker\}, Alexander and Rystsov, \{Gleb K.\} and Zemskova, \{Marina Y.\} and Zhelifonova, \{Valentina P.\} and Ivanushkina, \{Natalya E.\} and Kozlovsky, \{Anatoly G.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = nov,

day = "15",

doi = "10.1016/j.bmcl.2019.126708",

language = "English",

volume = "29",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

AU - Antipova, Tatiana V.

AU - Zaitsev, Kirill V.

AU - Oprunenko, Yuri F.

AU - Ya. Zherebker, Alexander

AU - Rystsov, Gleb K.

AU - Zemskova, Marina Y.

AU - Zhelifonova, Valentina P.

AU - Ivanushkina, Natalya E.

AU - Kozlovsky, Anatoly G.

PY - 2019/11/15

Y1 - 2019/11/15

N2 - Two new austalide meroterpenoids, named austalides V and W (1 and 2), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G), a structural fragment, first found in austalides. Austalides V (1) and W (2) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.

AB - Two new austalide meroterpenoids, named austalides V and W (1 and 2), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G), a structural fragment, first found in austalides. Austalides V (1) and W (2) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.

KW - AKT-mTORC1 signaling pathway

KW - Aspergillus ustus

KW - Austalide

KW - Fungus

KW - Prostate and bladder cancer cells

UR - https://www.scopus.com/pages/publications/85073055936

U2 - 10.1016/j.bmcl.2019.126708

DO - 10.1016/j.bmcl.2019.126708

M3 - Article

C2 - 31607610

AN - SCOPUS:85073055936

SN - 0960-894X

VL - 29

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

M1 - 126708

ER -

Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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