Author Correction: Increased emergency cardiovascular events among under-40 population in Israel during vaccine rollout and third COVID-19 wave (Scientific Reports, (2022), 12, 1, (6978), 10.1038/s41598-022-10928-z)

Correction to: Scientific Reports, published online 28 April 2022 The original version of this Article contained errors. First, in calculating the Spearman rank correlations between the time-series of weekly administered vaccine doses and COVID-19 infections, respectively, with the sum of the weekly emergency medical service (EMS) CA and ACS call counts, we discovered a coding error in calculating the latter time series. Specifically, the application of the incorrect code function led to concatenating the two time-series (CA and ACS weekly calls) instead of summing them. This was accompanied by an error in the corresponding post hoc power analysis, specifically, applying the post-hoc power software with the wrong (larger) input sample size parameters resulting in incorrect higher post-hoc power values. Correcting these errors led to higher Spearman correlation factors and lower p-values, as well as corrected post-hoc power values. Finally, we found an error in how data were extracted for a small fraction of EMS calls with multiple records as a result of multiple ambulances called to the scene. This correction led to a more accurate determination of the age range as well as the diagnosis of these calls, and resulted in very small changes in the number of weekly EMS calls included in the analyses, as well as in the corresponding Tables and Figures. As a result, in the Abstract, “An increase of over 25% was detected in both call types during January–May 2021, compared with the years 2019–2020” now reads: “An increase of 25% was detected in both call types during January–May 2021, compared with the years 2019–2020” In the Results section, subheading ‘General descriptive results’, “Of the 30262 cardiac arrest and 60398 ACS calls included in the study population (see Supplementary Results for details), 945 (3.1%) and 3945 (6.5%) calls were for patients of age 16–39, respectively” now reads: “Of the 30481 cardiac arrest and 61001 ACS calls included in the study population (see Supplementary Results for details), 952 (3.1%) and 3994 (6.5%) calls were for patients of age 16–39, respectively” In the Results section, subheading ‘Year-to-year changes in CA and ACS calls’, “Table 1 summarizes the year-to-year changes in CA and ACS call volume. The results highlight a statistically significant increase of over 25% in both CA (25.7%, P<0.05) and ACS (26.0%, P<0.001) calls for patients of ages 16–39 during January-May 2021, compared to the same period in 2020. Interestingly, for CA, there is no statistically significant difference in the respective call volume across the full year (January-December) from 2019 to 2020 (relative decrease of −2.4% [P=0.740]), prior to the vaccination rollout and third COVID-19 wave in this age group. Similarly, for ACS, the increase across the full year from 2019 and 2020 (significant relative increase of 15.8% [P<0.001]) was followed by an even a larger increase in the January to May period from 2020 to 2021 (significant relative increase of 26.0% [P<0.001]), which was during the third COVID-19 wave and vaccination rollout. Both genders in the 16–39 age group experienced increases in CA and ACS calls from 2020 to 2021 for January-May. Among males, CA calls increased by 25.0% (P=0.073) and ACS calls increased significantly by 21.3% (P<0.01). Among females, CA calls increased by 31.4% (P=0.224) and ACS calls instead significantly by 40.8% (P<0.01).” now reads: “Table 1 summarizes the year-to-year changes in CA and ACS call volume. The results highlight a statistically significant increase of 25% in both CA (25.7%, P < 0.05) and ACS (24.6%, P < 0.001) calls for patients of ages 16–39 during January–May 2021, compared to the same period in 2020. Interestingly, for CA, there is no statistically significant difference in the respective call volume across the full year (January–December) from 2019 to 2020 (relative increase of 0.5% [P=0.942]), prior to the vaccination rollout and third COVID-19 wave in this age group. Similarly, for ACS, the increase across the full year from 2019 and 2020 (significant relative increase of 15.8% [P < 0.001]) was followed by an even larger increase in the January to May period from 2020 to 2021 (significant relative increase of 24.6% [P < 0.001]), which was during the third COVID-19 wave and vaccination rollout. Both genders in the 16–39 age group experienced increases in CA and ACS calls from 2020 to 2021 for January–May. Among males, CA calls increased by 27.0% (P = 0.055) and ACS calls increased significantly by 20.4% (P < 0.01). Among females, CA calls increased by 25.0% (P = 0.321) and ACS calls instead significantly by 37.7% (P < 0.01).” And, “Among the 16–39 age group, the percent of CA patients that died prior to hospital arrival increased significantly from 2019 to 2020 during the full year (52.8% to 60.5%; P<0.001). This percent remained elevated during January-May of 2021 and no significant differences were found between same period in 2020 (65.1% to 61.3% P=0.460).