Autoantibodies in male homosexuals and HIV infection

Shmuel Argov; Ami Schattner; Rimona Burstein; Zeev T. Handzel; Yehuda Shoenfeld; Zvi Bentwich

doi:10.1016/0165-2478(91)90086-P

Autoantibodies in male homosexuals and HIV infection

Shmuel Argov, Ami Schattner, Rimona Burstein, Zeev T. Handzel, Yehuda Shoenfeld, Zvi Bentwich

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We have used ELISA to study the frequency of autoantibodies to several antigens in the serum of 17 male homosexuals (MHS) negative for HIV (HIV^-), 11 asymptomatic HIV seropositive MHS (HIV⁺) and patients with ARC (N = 15) or AIDS (N = 13), and compared them to 20 matched healthy heterosexual controls. Serum antibody binding to histones, cardiolipin, ss-A, ss-B and Sm was found to be significantly higher in each of the MHS groups studied as compared to controls (P<0.001), and was also increased in the HIV⁺ patients vs. the HIV^- group (P<0.05). In contrast, no increase in autoantibodies to ss-DNA, ds-DNA, poly(I), poly(G) or RNP were found in any of the groups tested. These results enlarge the spectrum of autoimmunity previously reported in HIV infection and identify a similar pattern to a lesser degree, already present in HIV^- MHS, suggesting a role for HIV or concomitant virus infections in its pathogenesis.

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Immunology Letters
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(91)90086-P
State	Published - 1 Jan 1991
Externally published	Yes

Keywords

AIDS
Antinuclear antibody
Autoantibody
Autoimmunity
HIV
Homosexual

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-2478(91)90086-P

Cite this

@article{3d0c339a10864e7cb0039d86431a0835,

title = "Autoantibodies in male homosexuals and HIV infection",

abstract = "We have used ELISA to study the frequency of autoantibodies to several antigens in the serum of 17 male homosexuals (MHS) negative for HIV (HIV-), 11 asymptomatic HIV seropositive MHS (HIV+) and patients with ARC (N = 15) or AIDS (N = 13), and compared them to 20 matched healthy heterosexual controls. Serum antibody binding to histones, cardiolipin, ss-A, ss-B and Sm was found to be significantly higher in each of the MHS groups studied as compared to controls (P<0.001), and was also increased in the HIV+ patients vs. the HIV- group (P<0.05). In contrast, no increase in autoantibodies to ss-DNA, ds-DNA, poly(I), poly(G) or RNP were found in any of the groups tested. These results enlarge the spectrum of autoimmunity previously reported in HIV infection and identify a similar pattern to a lesser degree, already present in HIV- MHS, suggesting a role for HIV or concomitant virus infections in its pathogenesis.",

keywords = "AIDS, Antinuclear antibody, Autoantibody, Autoimmunity, HIV, Homosexual",

author = "Shmuel Argov and Ami Schattner and Rimona Burstein and Handzel, {Zeev T.} and Yehuda Shoenfeld and Zvi Bentwich",

year = "1991",

month = jan,

day = "1",

doi = "10.1016/0165-2478(91)90086-P",

language = "English",

volume = "30",

pages = "31--35",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Autoantibodies in male homosexuals and HIV infection

AU - Argov, Shmuel

AU - Schattner, Ami

AU - Burstein, Rimona

AU - Handzel, Zeev T.

AU - Shoenfeld, Yehuda

AU - Bentwich, Zvi

PY - 1991/1/1

Y1 - 1991/1/1

N2 - We have used ELISA to study the frequency of autoantibodies to several antigens in the serum of 17 male homosexuals (MHS) negative for HIV (HIV-), 11 asymptomatic HIV seropositive MHS (HIV+) and patients with ARC (N = 15) or AIDS (N = 13), and compared them to 20 matched healthy heterosexual controls. Serum antibody binding to histones, cardiolipin, ss-A, ss-B and Sm was found to be significantly higher in each of the MHS groups studied as compared to controls (P<0.001), and was also increased in the HIV+ patients vs. the HIV- group (P<0.05). In contrast, no increase in autoantibodies to ss-DNA, ds-DNA, poly(I), poly(G) or RNP were found in any of the groups tested. These results enlarge the spectrum of autoimmunity previously reported in HIV infection and identify a similar pattern to a lesser degree, already present in HIV- MHS, suggesting a role for HIV or concomitant virus infections in its pathogenesis.

AB - We have used ELISA to study the frequency of autoantibodies to several antigens in the serum of 17 male homosexuals (MHS) negative for HIV (HIV-), 11 asymptomatic HIV seropositive MHS (HIV+) and patients with ARC (N = 15) or AIDS (N = 13), and compared them to 20 matched healthy heterosexual controls. Serum antibody binding to histones, cardiolipin, ss-A, ss-B and Sm was found to be significantly higher in each of the MHS groups studied as compared to controls (P<0.001), and was also increased in the HIV+ patients vs. the HIV- group (P<0.05). In contrast, no increase in autoantibodies to ss-DNA, ds-DNA, poly(I), poly(G) or RNP were found in any of the groups tested. These results enlarge the spectrum of autoimmunity previously reported in HIV infection and identify a similar pattern to a lesser degree, already present in HIV- MHS, suggesting a role for HIV or concomitant virus infections in its pathogenesis.

KW - AIDS

KW - Antinuclear antibody

KW - Autoantibody

KW - Autoimmunity

KW - HIV

KW - Homosexual

UR - http://www.scopus.com/inward/record.url?scp=0025916475&partnerID=8YFLogxK

U2 - 10.1016/0165-2478(91)90086-P

DO - 10.1016/0165-2478(91)90086-P

M3 - Article

C2 - 1959941

AN - SCOPUS:0025916475

SN - 0165-2478

VL - 30

SP - 31

EP - 35

JO - Immunology Letters

JF - Immunology Letters

IS - 1

ER -

Autoantibodies in male homosexuals and HIV infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this