Autoantibodies in male homosexuals and HIV infection

Shmuel Argov, Ami Schattner, Rimona Burstein, Zeev T. Handzel, Yehuda Shoenfeld, Zvi Bentwich

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


We have used ELISA to study the frequency of autoantibodies to several antigens in the serum of 17 male homosexuals (MHS) negative for HIV (HIV-), 11 asymptomatic HIV seropositive MHS (HIV+) and patients with ARC (N = 15) or AIDS (N = 13), and compared them to 20 matched healthy heterosexual controls. Serum antibody binding to histones, cardiolipin, ss-A, ss-B and Sm was found to be significantly higher in each of the MHS groups studied as compared to controls (P<0.001), and was also increased in the HIV+ patients vs. the HIV- group (P<0.05). In contrast, no increase in autoantibodies to ss-DNA, ds-DNA, poly(I), poly(G) or RNP were found in any of the groups tested. These results enlarge the spectrum of autoimmunity previously reported in HIV infection and identify a similar pattern to a lesser degree, already present in HIV- MHS, suggesting a role for HIV or concomitant virus infections in its pathogenesis.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalImmunology Letters
Issue number1
StatePublished - 1 Jan 1991
Externally publishedYes


  • AIDS
  • Antinuclear antibody
  • Autoantibody
  • Autoimmunity
  • HIV
  • Homosexual

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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