Autoantibody explosion in antiphospholipid syndrome

Yehuda Shoenfeld, Gilad Twig, Uriel Katz, Yaniv Sherer

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

Antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss in the presence of antiphospholipid antibodies (aPL), mainly anticardiolipin, anti-beta2-glycoprotein I and lupus anticoagulant. However, similar to systemic lupus erythematosus, APS is also characterized by multiple other autoantibodies including 'non-classical' aPL, as well as other antibodies. Herein we describe the autoantigen properties, prevalence and clinical importance of 30 different antibodies in APS. Among the other antibodies characterizing APS are autoantibodies directed to platelets, glycoproteins, various coagulation factors, lamins, mitochondrial antigens and cell surface markers. Few of these autoantibodies are correlated with the presence of other antibodies, and some may have an additive role in the pro-thrombotic tendency of the syndrome. This autoantibody explosion might be important in early identification of the syndrome and its manifestations.

Original languageEnglish
Pages (from-to)74-83
Number of pages10
JournalJournal of Autoimmunity
Volume30
Issue number1-2
DOIs
StatePublished - 1 Feb 2008
Externally publishedYes

Keywords

  • Anticardiolipin
  • Antiphospholipid syndrome
  • Autoantibody
  • Lupus anticoagulant
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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