Autoantibody explosion in systemic lupus erythematosus: More than 100 different antibodies found in SLE patients

Yaniv Sherer, Alexander Gorstein, Marvin J. Fritzler, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

485 Scopus citations

Abstract

OBJECTIVE: Description of the various autoantibodies that can be detected in patients with systemic lupus erythematosus (SLE). METHODS: A literature review, using the terms "autoantibody" and "systemic lupus erythematosus", was conducted to search for articles on autoantibodies in SLE, their target antigens, association with disease activity, or other clinical associations. RESULTS: One hundred sixteen autoantibodies were described in SLE patients. These include autoantibodies that target nuclear antigens, cytoplasmic antigens, cell membrane antigens, phospholipid-associated antigens, blood cells, endothelial cells, and nervous system antigens, plasma proteins, matrix proteins, and miscellaneous antigens. The target of autoantibody, the autoantigen properties, autoantibody frequencies in SLE, as well as clinical associations, and correlation with disease activity are described for all 116 autoantibodies. CONCLUSIONS: SLE is the autoimmune disease with the largest number of detectable autoantibodies. Their production could be antigen-driven, the result of polyclonal B cell activation, impaired apoptotic pathways, or the outcome of idiotypic network dysregulation.

Original languageEnglish
Pages (from-to)501-537
Number of pages37
JournalSeminars in Arthritis and Rheumatism
Volume34
Issue number2
DOIs
StatePublished - 1 Jan 2004
Externally publishedYes

Keywords

  • Apoptosis
  • Autoantibody
  • Epitope spreading
  • Idiotype
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

Fingerprint

Dive into the research topics of 'Autoantibody explosion in systemic lupus erythematosus: More than 100 different antibodies found in SLE patients'. Together they form a unique fingerprint.

Cite this