Autoinducer N-(3-oxododecanoyl)-L-homoserine lactone induces calcium and reactive oxygen species-mediated mitochondrial damage and apoptosis in blood platelets

Keyphrases

• Platelets 100%
• Reactive Oxygen Species 100%
• Mitochondrial Damage 100%
• Blood Platelets 100%
• Homoserine Lactone 100%
• Homoserine 100%
• Autoinducer-2 (AI-2) 100%
• Mitochondrial Apoptosis 100%
• Pseudomonas Aeruginosa (P. aeruginosa) 66%
• Mitochondrial Dysfunction 66%
• Phosphatidylserine Exposure 66%
• ROS Production 66%
• Acylated Homoserine Lactones 66%
• Mitochondrial Permeability Transition Pore 33%
• Virulence Factors 33%
• Host Cell 33%
• Induced Apoptosis 33%
• Potential Loss 33%
• Cytosolic Ca2+ 33%
• Infected Individual 33%
• Thrombotic Complications 33%
• Intracellular Ca2+ 33%
• Intracellular Calcium 33%
• Thrombin 33%
• Platelet Aggregation 33%
• Mitochondrial Transmembrane Potential 33%
• Calcium Chelator 33%
• Human Blood Platelets 33%
• Clot Retraction 33%
• Pore Formation 33%
• BAPTA-AM 33%
• Production Results 33%
• ROS Inhibitors 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Reactive Oxygen Metabolite 100%
• Carbon 100%
• Lactone 100%
• Homoserine 100%
• Pseudomonas aeruginosa 28%
• Calcium Ion 28%
• Phosphatidylserine 28%
• Virulence Factor 14%
• Thrombin 14%
• Calcium Chelating Agent 14%
• Ethylene Glycol 1,2 Bis(2 Aminophenyl) Ether N,n,n',n' Tetraacetic Acid 14%
• Mitochondrial Permeability Transition Pore 14%

Biochemistry, Genetics and Molecular Biology

• Platelet 100%
• Autoinducer 100%
• Pseudomonas aeruginosa 40%
• Phosphatidylserine 40%
• Mitochondrial Permeability Transition Pore 20%
• Membrane Potential 20%
• Channel Gating 20%
• Calcium Cell Level 20%
• Thrombin 20%
• Virulence Factor 20%
• Thrombocyte Aggregation 20%
• Clot Retraction 20%