Avian Lymphokines: 1. Thymic Cell Growth Factor in Supernatants of Mitogen Stimulated Chicken Spleen Cells

K. Schauenstein; A. Globerson; G. Wick

doi:10.1016/S0145-305X(82)80039-6

Avian Lymphokines: 1. Thymic Cell Growth Factor in Supernatants of Mitogen Stimulated Chicken Spleen Cells

K. Schauenstein, A. Globerson, G. Wick

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Abstract

The present study provides first evidence for the presence of a thymic cell growth factor (TCGF) in supernatants (20 hrs) of mitogen (Con A) stimulated chicken spleen cells. 2 out of 3 batches of supernatant prepared according to a procedure originally described for the mouse system (10) induced a vigorous proliferative response of Con A prestimulated chicken spleen cells without significant mitogenic effect on unstimulated lymphocytes. No crossreactivity of this chicken-TCGF was observed with prestimulated murine lymphocytes, nor did potent mouse-TCGF preparations exhibit any proliferative effect on chicken cells. The implications of these data for both phylogenetic as well as practical experimental aspects are discussed.

Original language	English
Pages (from-to)	533-540
Number of pages	8
Journal	Developmental and Comparative Immunology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/S0145-305X(82)80039-6
State	Published - 1 Jan 1982
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Developmental Biology
Immunology

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title = "Avian Lymphokines: 1. Thymic Cell Growth Factor in Supernatants of Mitogen Stimulated Chicken Spleen Cells",

abstract = "The present study provides first evidence for the presence of a thymic cell growth factor (TCGF) in supernatants (20 hrs) of mitogen (Con A) stimulated chicken spleen cells. 2 out of 3 batches of supernatant prepared according to a procedure originally described for the mouse system (10) induced a vigorous proliferative response of Con A prestimulated chicken spleen cells without significant mitogenic effect on unstimulated lymphocytes. No crossreactivity of this chicken-TCGF was observed with prestimulated murine lymphocytes, nor did potent mouse-TCGF preparations exhibit any proliferative effect on chicken cells. The implications of these data for both phylogenetic as well as practical experimental aspects are discussed.",

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AU - Globerson, A.

AU - Wick, G.

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N2 - The present study provides first evidence for the presence of a thymic cell growth factor (TCGF) in supernatants (20 hrs) of mitogen (Con A) stimulated chicken spleen cells. 2 out of 3 batches of supernatant prepared according to a procedure originally described for the mouse system (10) induced a vigorous proliferative response of Con A prestimulated chicken spleen cells without significant mitogenic effect on unstimulated lymphocytes. No crossreactivity of this chicken-TCGF was observed with prestimulated murine lymphocytes, nor did potent mouse-TCGF preparations exhibit any proliferative effect on chicken cells. The implications of these data for both phylogenetic as well as practical experimental aspects are discussed.

AB - The present study provides first evidence for the presence of a thymic cell growth factor (TCGF) in supernatants (20 hrs) of mitogen (Con A) stimulated chicken spleen cells. 2 out of 3 batches of supernatant prepared according to a procedure originally described for the mouse system (10) induced a vigorous proliferative response of Con A prestimulated chicken spleen cells without significant mitogenic effect on unstimulated lymphocytes. No crossreactivity of this chicken-TCGF was observed with prestimulated murine lymphocytes, nor did potent mouse-TCGF preparations exhibit any proliferative effect on chicken cells. The implications of these data for both phylogenetic as well as practical experimental aspects are discussed.

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Avian Lymphokines: 1. Thymic Cell Growth Factor in Supernatants of Mitogen Stimulated Chicken Spleen Cells

Abstract

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