TY - JOUR
T1 - Bacterial resistance in the intensive care unit of developing countries
T2 - Report from a tertiary hospital in Kazakhstan
AU - Viderman, Dmitriy
AU - Brotfain, Evgeni
AU - Khamzina, Yekaterina
AU - Kapanova, Gulnara
AU - Zhumadilov, Agzam
AU - Poddighe, Dimitri
N1 - Publisher Copyright:
© 2018 International Society for Chemotherapy of Infection and Cancer
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Objectives: The aim of this study was to describe the patterns of antimicrobial resistance (AMR) of bacterial isolates causing hospital-acquired infections (HAIs) in the intensive care unit (ICU) of a tertiary hospital in Kazakhstan. Methods: This was a retrospective analysis of AMR in the ICU of the National Research Center for Oncology and Transplantation (Astana, Kazakhstan) during the year 2015. Results: During the study period, 546 patients were admitted to the ICU, of whom 135 (24.7%) developed at least one HAI. Most HAIs caused by Gram-positive bacteria were due to Enterococcus faecalis, which were resistant to aminoglycosides in >70% cases. Gram-negative bacteria were isolated in ca. 50% of cases, thus representing the greatest burden of HAIs. Very high resistance rates to ceftriaxone, cefotaxime and cefuroxime were observed. Moreover, Pseudomonas aeruginosa and Acinetobacter baumannii were resistant to carbapenems in <20% and in ca. 45% of cases, respectively. Conclusion: This study demonstrates the urgent need to implement more rational use of antimicrobials in Kazakhstan, which can be done only by establishing a proactive surveillance system along with an appropriate infection control programme.
AB - Objectives: The aim of this study was to describe the patterns of antimicrobial resistance (AMR) of bacterial isolates causing hospital-acquired infections (HAIs) in the intensive care unit (ICU) of a tertiary hospital in Kazakhstan. Methods: This was a retrospective analysis of AMR in the ICU of the National Research Center for Oncology and Transplantation (Astana, Kazakhstan) during the year 2015. Results: During the study period, 546 patients were admitted to the ICU, of whom 135 (24.7%) developed at least one HAI. Most HAIs caused by Gram-positive bacteria were due to Enterococcus faecalis, which were resistant to aminoglycosides in >70% cases. Gram-negative bacteria were isolated in ca. 50% of cases, thus representing the greatest burden of HAIs. Very high resistance rates to ceftriaxone, cefotaxime and cefuroxime were observed. Moreover, Pseudomonas aeruginosa and Acinetobacter baumannii were resistant to carbapenems in <20% and in ca. 45% of cases, respectively. Conclusion: This study demonstrates the urgent need to implement more rational use of antimicrobials in Kazakhstan, which can be done only by establishing a proactive surveillance system along with an appropriate infection control programme.
KW - Antimicrobial resistance
KW - Carbapenems
KW - Developing countries
KW - Hospital-acquired infection
KW - Intensive care unit
UR - https://www.scopus.com/pages/publications/85063079770
U2 - 10.1016/j.jgar.2018.11.010
DO - 10.1016/j.jgar.2018.11.010
M3 - Article
C2 - 30448518
AN - SCOPUS:85063079770
SN - 2213-7165
VL - 17
SP - 35
EP - 38
JO - Journal of Global Antimicrobial Resistance
JF - Journal of Global Antimicrobial Resistance
ER -