Bacteriophage T4 development in Escherichia coli is growth rate dependent

Avinoam Rabinovitch, Itzhak Fishov, Hilla Hadas, Monica Einav, Arieh Zaritsky

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Three independent parameters (eclipse and latent periods, and rate of ripening during the rise period) are essential and sufficient to describe bacteriophage development in its bacterial host. A general model to describe the classical "one-step growth" experiment [Rabinovitch et al. (1999a) J. Bacteriol. 181, 1687-1683] allowed their calculations from experimental results obtained with T4 in Escherichia coli B/r under different growth conditions [Hadas et al. (1997) Microbiology 143, 179-185]. It is found that all three parameters could be described by their dependence solely on the culture doubling time τ before infection. Their functional dependence on τ, derived by a best-fit analysis, was used to calculate burst size values. The latter agree well with the experimental results. The dependence of the derived parameters on growth conditions can be used to predict phage development under other experimental manipulations.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalJournal of Theoretical Biology
Volume216
Issue number1
DOIs
StatePublished - 1 Jan 2002

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology (all)
  • Immunology and Microbiology (all)
  • Agricultural and Biological Sciences (all)
  • Applied Mathematics

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