Baker's yeast catalyzed asymmetric reduction in glycerol

Adi Wolfson; Christina Dlugy; Dorith Tavor; Janine Blumenfeld; Yoram Shotland

doi:10.1016/j.tetasy.2006.07.026

Baker's yeast catalyzed asymmetric reduction in glycerol

Adi Wolfson, Christina Dlugy, Dorith Tavor, Janine Blumenfeld, Yoram Shotland

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Free and immobilized baker's yeast were successfully employed in the asymmetric hydrogenations of prochiral β-keto esters and ketones in glycerol. The activities with immobilized cells were always higher then with free cells while the enantioselectivity was very high (99%) with both catalysts. Using glycerol, a non-toxic, biodegradable and recyclable liquid, as an environmentally friendly solvent allowed easy separation of the product by simple extraction with diethyl ether.

Original language	English
Pages (from-to)	2043-2045
Number of pages	3
Journal	Tetrahedron Asymmetry
Volume	17
Issue number	14
DOIs	https://doi.org/10.1016/j.tetasy.2006.07.026
State	Published - 28 Aug 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/j.tetasy.2006.07.026

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title = "Baker's yeast catalyzed asymmetric reduction in glycerol",

abstract = "Free and immobilized baker's yeast were successfully employed in the asymmetric hydrogenations of prochiral β-keto esters and ketones in glycerol. The activities with immobilized cells were always higher then with free cells while the enantioselectivity was very high (99\%) with both catalysts. Using glycerol, a non-toxic, biodegradable and recyclable liquid, as an environmentally friendly solvent allowed easy separation of the product by simple extraction with diethyl ether.",

author = "Adi Wolfson and Christina Dlugy and Dorith Tavor and Janine Blumenfeld and Yoram Shotland",

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AU - Wolfson, Adi

AU - Dlugy, Christina

AU - Tavor, Dorith

AU - Blumenfeld, Janine

AU - Shotland, Yoram

PY - 2006/8/28

Y1 - 2006/8/28

N2 - Free and immobilized baker's yeast were successfully employed in the asymmetric hydrogenations of prochiral β-keto esters and ketones in glycerol. The activities with immobilized cells were always higher then with free cells while the enantioselectivity was very high (99%) with both catalysts. Using glycerol, a non-toxic, biodegradable and recyclable liquid, as an environmentally friendly solvent allowed easy separation of the product by simple extraction with diethyl ether.

AB - Free and immobilized baker's yeast were successfully employed in the asymmetric hydrogenations of prochiral β-keto esters and ketones in glycerol. The activities with immobilized cells were always higher then with free cells while the enantioselectivity was very high (99%) with both catalysts. Using glycerol, a non-toxic, biodegradable and recyclable liquid, as an environmentally friendly solvent allowed easy separation of the product by simple extraction with diethyl ether.

UR - https://www.scopus.com/pages/publications/33747809949

U2 - 10.1016/j.tetasy.2006.07.026

DO - 10.1016/j.tetasy.2006.07.026

M3 - Article

AN - SCOPUS:33747809949

SN - 0957-4166

VL - 17

SP - 2043

EP - 2045

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 14

ER -

Baker's yeast catalyzed asymmetric reduction in glycerol

Abstract

ASJC Scopus subject areas

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