Base-catalyzed Mukaiyama-type aldol additions, a continued quest for stereoselectivity

Revannath L. Sutar, Navalkishore N. Joshi

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Base-catalyzed reactions of silyl enolates with carbonyl compounds are an attractive variant of conventional directed aldol reactions. Over the past two decades, the reaction has gained prominence due to its inherent advantage for stereoselective manipulations. The present review provides a brief account of developments in this area. Various approaches are grouped together in order to provide the salient features of each conceptual development. It appears that the methods which generate nascent chiral enolates or cationic siliconium species have the biggest influence on the stereoselectivity.

Original languageEnglish
Pages (from-to)1345-1363
Number of pages19
JournalTetrahedron Asymmetry
Issue number21-22
StatePublished - 30 Nov 2013
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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