Bcl-2 and MALT1 genes are not involved in the oncogenesis of uterine tumors resembling ovarian sex cord tumors

Sanda Šitić, Petra Korać, Petra Peharec, Gojko Zovko, Marija Milković Periša, Slavko Gašparov

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare entities. They were described by Clement and Scully in 1976 who classified them into groups I and II. Group I comprises typical endometrial stromal neoplasms with focal areas resembling ovarian sex cord elements and group II are predominantly or completely composed of ovarian sex cord-like elements. We report a case of UTROSCT type II with cytogenetic analysis. The tumor occurred in a 76-year-old woman who presented with vaginal bleeding. The tumor was lobulated, firm, yellow and histologically composed of sex cord-like elements. Tumor cells expressed vimentin, CD10, CD99 and alpha-actin. Cytogenetic analysis in a previously reported case detected translocation t(4;18)(q21.1;q21.3) in the majority of cells. Bcl-2 and MALT1 genes are located at or near the translocation breakpoints, and the aim of this study was to determine whether these genes were involved in chromosomal translocation or tumorigenesis. We did not find IgH translocation or the most common MALT translocations. Bcl-2 was also not involved in this oncogenesis.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalPathology and Oncology Research
Volume13
Issue number2
DOIs
StatePublished - 1 Jan 2007
Externally publishedYes

Keywords

  • Bcl-2
  • MALT1
  • Ovarian sex cord tumors
  • Translocation
  • Uterus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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