Benign course and clinical features of COVID-19 in hospitalised febrile infants up to 60 days old

Havazelet Yarden Bilavski, Sarit Balanson, Ranaa Damouni Shalabi, Halima Dabaja-Younis, Galia Grisaru-Soen, Ilan Youngster, Daniel Glikman, Shalom Ben Shimol, Eli Somech, Diana Tasher, Michal Stein, Giora Gottesmanm, Gilat Livni, Orli Megged

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Aim: Minimal data exist regarding the severity of COVID-19 in febrile infants under 60 days old. This multicentre prospective study explored the clinical course and outcomes of this hospitalised patient population, as, to date, the best approach has not been specifically addressed. Methods: This study focused on the clinical features, laboratory parameters and outcomes of febrile infants up to 60 days old who tested positive for the virus and were hospitalised in Israel from March 2020 to January 2021. The data were extracted from a real-time prospective surveillance network for COVID-19 that includes 20 of the country's 26 hospitals. Results: We identified 75 febrile young infants (60% female) with COVID-19 at a median age of 28 days (range 8–56 days). Of these, 84% had an unremarkable medical history, 29% had respiratory symptoms, and 96% had a mild illness. The Rochester criteria showed that 44% were considered at high-risk for serious bacterial infections, and we found that eight infants actually had concomitant bacterial infections. Outcomes were excellent, and no complications or fatalities were reported. Conclusion: The excellent outcomes of young febrile infants with COVID-19 closely resembled other respiratory viral aetiologies of fever in this age group, and there were no fatalities.

Original languageEnglish
Pages (from-to)2790-2795
Number of pages6
JournalActa Paediatrica, International Journal of Paediatrics
Issue number10
StatePublished - 1 Oct 2021


  • COVID-19
  • Rochester criteria
  • infants
  • neonatal fever
  • serious bacterial infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Benign course and clinical features of COVID-19 in hospitalised febrile infants up to 60 days old'. Together they form a unique fingerprint.

Cite this