Benign nasopharyngeal lymphoid tumors, lymphoepithelial lesions, and lymphocytic interstitial pneumonitis

Marco Puterman, Dan M. Fliss, Jed Coldstein, Howard Zirkin

Research output: Contribution to journalArticlepeer-review

Abstract

A clinico‐pathologic and immunologic case study of a 57‐year‐old woman who has shown progressive lymphoid proliferations and lymphocyte dysfunction over the course of 10 years is presented. Early in the course ofher disease, she presented with recurrent benign nasopharyngeal lymphoid tumors. She subsequently developedbenign lymphoepithelial lesions involving both a submandibular and then a parotid salivary gland. She eventually underwent pneumonectomy for lymphocytic interstitial pneumonitis with marked cystic degeneration and lung destruction. Although frank malignancy has not been demonstrated review of her nasopharyngeal biopsies andof her pulmonary pathology shows a tendency toward distinct cellular uniformity with loss of follicles and germinal centers. Concurrently, immunologic studies have demonstrated abnormalities of cell mediated (T cell)function.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalJournal of Surgical Oncology
Volume39
Issue number1
DOIs
StatePublished - 1 Jan 1988

Keywords

  • benign lymphoepithelial lesions
  • lymphocytic interstitial pneumonitis
  • recurrent benign nasopharyngeal tumors

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