TY - JOUR
T1 - Bifunctional Carbon-Dot-WS2 Nanorods for Photothermal Therapy and Cell Imaging
AU - Nandi, Sukhendu
AU - Bhunia, Susanta Kumar
AU - Zeiri, Leila
AU - Pour, Maayan
AU - Nachman, Iftach
AU - Raichman, Daniel
AU - Lellouche, Jean Paul Moshe
AU - Jelinek, Raz
N1 - Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/1/18
Y1 - 2017/1/18
N2 - Multifunctional nanoparticles have attracted significant interest as biomedical vehicles, combining diagnostic, imaging, and therapeutic properties. We describe herein the construction of new nanoparticle conjugates comprising WS2 nanorods (NRs) coupled to fluorescent carbon dots (C-dots). We show that the WS2-C-dot hybrids integrate the unique physical properties of the two species, specifically the photothermal activity of the WS2 NRs upon irradiation with near-infrared (NIR) light and the excitation-dependent luminescence emission of the C-dots. The WS2-C-dot NRs have been shown to be non-cytotoxic and have been successfully employed for multicolour cell imaging and targeted cell killing under NIR irradiation, pointing to their potential utilization as effective therapeutic vehicles.
AB - Multifunctional nanoparticles have attracted significant interest as biomedical vehicles, combining diagnostic, imaging, and therapeutic properties. We describe herein the construction of new nanoparticle conjugates comprising WS2 nanorods (NRs) coupled to fluorescent carbon dots (C-dots). We show that the WS2-C-dot hybrids integrate the unique physical properties of the two species, specifically the photothermal activity of the WS2 NRs upon irradiation with near-infrared (NIR) light and the excitation-dependent luminescence emission of the C-dots. The WS2-C-dot NRs have been shown to be non-cytotoxic and have been successfully employed for multicolour cell imaging and targeted cell killing under NIR irradiation, pointing to their potential utilization as effective therapeutic vehicles.
KW - carbon dots
KW - cell imaging
KW - fluorescent probes
KW - multicolour fluorescence imaging
KW - nanostructures
KW - photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85007018532&partnerID=8YFLogxK
U2 - 10.1002/chem.201604787
DO - 10.1002/chem.201604787
M3 - Article
C2 - 27813177
AN - SCOPUS:85007018532
SN - 0947-6539
VL - 23
SP - 963
EP - 969
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 4
ER -