TY - JOUR
T1 - Bifurcation and chaos in a model of cardiac early afterdepolarizations
AU - Tran, Diana X.
AU - Sato, Daisuke
AU - Yochelis, Arik
AU - Weiss, James N.
AU - Garfinkel, Alan
AU - Qu, Zhilin
PY - 2009/6/25
Y1 - 2009/6/25
N2 - Excitable cells can exhibit complex patterns of oscillations, such as spiking and bursting. In cardiac cells, pathological voltage oscillations, called early afterdepolarizations (EADs), have been widely observed under disease conditions, yet their dynamical mechanisms remain unknown. Here, we show that EADs are caused by Hopf and homoclinic bifurcations. During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a distinct explanation for the irregular EAD behavior frequently observed in experiments.
AB - Excitable cells can exhibit complex patterns of oscillations, such as spiking and bursting. In cardiac cells, pathological voltage oscillations, called early afterdepolarizations (EADs), have been widely observed under disease conditions, yet their dynamical mechanisms remain unknown. Here, we show that EADs are caused by Hopf and homoclinic bifurcations. During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a distinct explanation for the irregular EAD behavior frequently observed in experiments.
UR - http://www.scopus.com/inward/record.url?scp=67649442642&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.102.258103
DO - 10.1103/PhysRevLett.102.258103
M3 - Article
AN - SCOPUS:67649442642
SN - 0031-9007
VL - 102
JO - Physical Review Letters
JF - Physical Review Letters
IS - 25
M1 - 258103
ER -