Bioabsorbable anti-inflammatory material: a novel protein-conjugated polymer with applications in the implantable medical device field

Crystal Rapier, Esther Chen, Wendy F. Liu, Abraham P. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this paper, we present a microfluidic method of creating hybrid protein-PLGA particles. We are combining the bioabsorbable property of PLGA and the antiinflammatory property of an immunomodulatory protein. We aim to assess whether this protein can inhibit inflammatory response to PLGA's acidic subunits as it degrades. Particles are made using a double emulsion and solvent extraction process. To date, our microfluidic system has been optimized to create single or multi-cavity particles, thin shell particles, and solid particles using a non-toxic solvent. In the near future we will characterize and compare the release profiles of the hybrid protein- PLGA particles vs. conventional protein encapsulated particles.

Original languageEnglish
Title of host publicationNSTI
Subtitle of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2015
EditorsMatthew Laudon, Bart Romanowicz
PublisherTaylor and Francis Inc.
Pages246-248
Number of pages3
ISBN (Electronic)9781498747295
StatePublished - 1 Jan 2015
Externally publishedYes
Event10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference - Washington, United States
Duration: 14 Jun 201517 Jun 2015

Publication series

NameNSTI: Advanced Materials - TechConnect Briefs 2015
Volume3

Conference

Conference10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference
Country/TerritoryUnited States
CityWashington
Period14/06/1517/06/15

Keywords

  • Antiinflammatory
  • Immunomodulatory
  • Microfluidics
  • Particles
  • PLGA
  • Stent

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Fluid Flow and Transfer Processes
  • Biotechnology
  • Fuel Technology

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