Biochip based on arrays of switchable magnetic nano-traps

Christopher Vautrin; Maria Vyazmensky; Stanislav Engel; Stephan Mc Murtry; Michel Hehn; François Montaigne; Daniel Lacour; Robert S. Marks

doi:10.1016/j.snb.2017.05.084

Biochip based on arrays of switchable magnetic nano-traps

Christopher Vautrin, Maria Vyazmensky, Stanislav Engel, Stephan Mc Murtry, Michel Hehn, François Montaigne, Daniel Lacour, Robert S. Marks

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Magnetic biochips based on switchable magnetic nano-traps were developed and optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution. Nano-traps are based on snake shaped magnetic nanowires made by microelectronic technics from a thin magnetic layer. This optimized design ensures high local fields when the trap is activated and reduced stray fields when deactivated with respect to previous designs. Our proof-of-concept model consists to determine the anchorage of synthetic peptides in a bilayer enveloping magnetic beads by revealing their presence via fluorescently labeled immunoglobulins elicited against the native proteins of the said exposed peptides.

Original language	English
Pages (from-to)	699-705
Number of pages	7
Journal	Sensors and Actuators, B: Chemical
Volume	251
DOIs	https://doi.org/10.1016/j.snb.2017.05.084
State	Published - 1 Jan 2017

Keywords

Bio-assay
Magnetic beads
Magnetic domains walls
Magnetic nano-traps
Peptide

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2017.05.084

Cite this

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title = "Biochip based on arrays of switchable magnetic nano-traps",

abstract = "Magnetic biochips based on switchable magnetic nano-traps were developed and optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution. Nano-traps are based on snake shaped magnetic nanowires made by microelectronic technics from a thin magnetic layer. This optimized design ensures high local fields when the trap is activated and reduced stray fields when deactivated with respect to previous designs. Our proof-of-concept model consists to determine the anchorage of synthetic peptides in a bilayer enveloping magnetic beads by revealing their presence via fluorescently labeled immunoglobulins elicited against the native proteins of the said exposed peptides.",

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AU - Vautrin, Christopher

AU - Vyazmensky, Maria

AU - Engel, Stanislav

AU - Murtry, Stephan Mc

AU - Hehn, Michel

AU - Montaigne, François

AU - Lacour, Daniel

AU - Marks, Robert S.

PY - 2017/1/1

Y1 - 2017/1/1

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AB - Magnetic biochips based on switchable magnetic nano-traps were developed and optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution. Nano-traps are based on snake shaped magnetic nanowires made by microelectronic technics from a thin magnetic layer. This optimized design ensures high local fields when the trap is activated and reduced stray fields when deactivated with respect to previous designs. Our proof-of-concept model consists to determine the anchorage of synthetic peptides in a bilayer enveloping magnetic beads by revealing their presence via fluorescently labeled immunoglobulins elicited against the native proteins of the said exposed peptides.

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KW - Magnetic domains walls

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JO - Sensors and Actuators, B: Chemical

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Biochip based on arrays of switchable magnetic nano-traps

Abstract

Keywords

ASJC Scopus subject areas

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