Biochip based on arrays of switchable magnetic nano-traps

Christopher Vautrin, Maria Vyazmensky, Stanislav Engel, Stephan Mc Murtry, Michel Hehn, François Montaigne, Daniel Lacour, Robert S. Marks

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Magnetic biochips based on switchable magnetic nano-traps were developed and optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution. Nano-traps are based on snake shaped magnetic nanowires made by microelectronic technics from a thin magnetic layer. This optimized design ensures high local fields when the trap is activated and reduced stray fields when deactivated with respect to previous designs. Our proof-of-concept model consists to determine the anchorage of synthetic peptides in a bilayer enveloping magnetic beads by revealing their presence via fluorescently labeled immunoglobulins elicited against the native proteins of the said exposed peptides.

Original languageEnglish
Pages (from-to)699-705
Number of pages7
JournalSensors and Actuators, B: Chemical
Volume251
DOIs
StatePublished - 1 Jan 2017

Keywords

  • Bio-assay
  • Magnetic beads
  • Magnetic domains walls
  • Magnetic nano-traps
  • Peptide

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