Biodegradable polycaprolactone-polyanhydrides blends

Shimon Ben-Shabat, Elias Abuganima, Aliza Raziel, Abraham J. Domb

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations

    Abstract

    Biodegradable polymers based on a blend of polycaprolactone (PCL) and aliphatic polyanhydrides with various monomer lengths were prepared to obtain desired polymer blends for use as drug carriers. The physicochemical, mechanical, and drug-release properties of these blends were investigated by various techniques to evaluate the uniformity degree of the polymer blends to establish their potential applications in drug delivery. The results demonstrated that the heat of fusion (Δ) of the polyanhydride or the blend is increased in relation to the length of the aliphatic chain. However, the blends had different properties than pure polyanhydride, and the crystallization degree of the blends, as expressed by the ΔH, decreased in relation to the ΔH of the pure polyanhydride. Drug-release studies from blends of PCL and aliphatic polyanhydrides demonstrated first-order kinetics of the release rate. Polymer degradation was independent at the polyanhydride monomer length. On the basis of theoretical calculation of the interaction factor, a blend of PCL and poly(dodecanedeoic anhydride) was chosen for further elucidation of its thermal, mechanical, and degradation properties.

    Original languageEnglish
    Pages (from-to)3781-3787
    Number of pages7
    JournalJournal of Polymer Science, Part A: Polymer Chemistry
    Volume41
    Issue number23
    DOIs
    StatePublished - 1 Dec 2003

    Keywords

    • Biodegradable
    • Blends
    • Drug delivery systems
    • Polyanhydrides
    • Polycaprolactone

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