Bioenergetic mechanisms of seizure control

Richard Kovács, Zoltan Gerevich, Alon Friedman, Jakub Otáhal, Ofer Prager, Siegrun Gabriel, Nikolaus Berndt

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Epilepsy is characterized by the regular occurrence of seizures, which follow a stereotypical sequence of alterations in the electroencephalogram. Seizures are typically a self limiting phenomenon, concluding finally in the cessation of hypersynchronous activity and followed by a state of decreased neuronal excitability which might underlie the cognitive and psychological symptoms the patients experience in the wake of seizures. Many efforts have been devoted to understand how seizures spontaneously stop in hope to exploit this knowledge in anticonvulsant or neuroprotective therapies. Besides the alterations in ion-channels, transmitters and neuromodulators, the successive build up of disturbances in energy metabolism have been suggested as a mechanism for seizure termination. Energy metabolism and substrate supply of the brain are tightly regulated by different mechanisms called neurometabolic and neurovascular coupling. Here we summarize the current knowledge whether these mechanisms are sufficient to cover the energy demand of hypersynchronous activity and whether a mismatch between energy need and supply could contribute to seizure control.

Original languageEnglish
Article number335
JournalFrontiers in Cellular Neuroscience
Volume12
DOIs
StatePublished - 8 Oct 2018

Keywords

  • Adenosine
  • Lactate
  • Neurometabolic coupling
  • Neurovascular coupling
  • Pericyte
  • Seizure

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