Bioengineering Alginate for Regenerative Medicine Applications

Emil Ruvinov, Smadar Cohen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

The global epidemic of chronic degenerative diseases represents an increasing burden on all healthcare systems. Regenerative medicine has promise to become the next generation therapy as this strategy can potentially restore/establish the normal function of damaged organs and tissues. Regeneration refers to engraftment of progenitor cells that require in vivo growth and differentiation to establish recipient homeostasis through de novo function of the stem cell-based transplant. An intense search is ongoing for tissue-specific stem cells that have the capacity to re-establish lost function when ectopically transplanted into a wide range of diseased tissues, as evident in diabetes, ischemic heart disease, and degenerative neurological diseases. Most regenerative medicine strategies rely on stem cells, growth factors, biomaterials, and their combination. The alginate hydrogel has been widely explored over the past several decades as a cell delivery vehicle for different cell populations intended to direct the regeneration and function restoration of various tissues and organs in the body.

Original languageEnglish
Title of host publicationBiomaterials from Nature for Advanced Devices and Therapies
PublisherWiley-Blackwell
Pages274-306
Number of pages33
ISBN (Electronic)9781119126218
ISBN (Print)9781118478059
DOIs
StatePublished - 1 Jan 2016

Keywords

  • Alginate hydrogel
  • Bioengineering alginate
  • Chronic degenerative diseases
  • Diabetes
  • Healthcare systems
  • Ischemic heart disease
  • Regenerative medicine
  • Stem cell-based transplant

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