Biogenic amine-related enzymes and personality variations in normals

D. L. Murphy, R. H. Belmaker, M. Buchsbaum, N. F. Martin, R. Ciaranello, R. J. Wyatt

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

Altered activities of biogenic amine-related enzymes have been reported in some studies of patients with affective disorders and chronic schizophrenia. To evaluate whether any relationship between personality variations, including non-diagnosed psychopathology, and these enzymes might occur in non-psychiatric patients, 95 young adult volunteers were studied. Higher MMPI and Zuckerman sensation-seeking scale scores were found in male, but not female, volunteers with lower platelet and plasma amine oxidase activities. Males generally exhibited negative correlations, while females had positive correlations between the psychological test scores and amine oxidase activities. In contrast to the amine oxidase results, no associations were observed between plasma dopamine β-hydroxylase activities and the personality variables.

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalPsychological Medicine
Volume7
Issue number1
DOIs
StatePublished - 1 Jan 1977
Externally publishedYes

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