Abstract
This report summarises phase 2 trial results of biologic lung volume reduction (BioLVR) for treatment of advanced homogeneous emphysema. BioLVR therapy was administered bronchoscopically to 25 patients with homogeneous emphysema in an open-labelled study. Eight patients received low dose (LD) treatment with 10 mL per site at eight subsegments; 17 received high dose (HD) treatment with 20 mL per site at eight subsegments. Safety was assessed in terms of medical complications during 6-month follow-up. Efficacy was assessed in terms of change from baseline in gas trapping, spirometry, diffusing capacity, exercise capacity, dyspnoea and health-related quality of life. There were no deaths or serious medical complications during the study. A statistically significant reduction in gas trapping was observed at 3-month follow-up among HD patients, but not LD patients. At 6 months, changes from baseline in forced expiratory volume in 1 s (-8.0±13.93% versus +13.8±20.26%), forced vital capacity (-3.9±9.41% versus +9.0±13.01%), residual volume/total lung capacity ratio (-1.4±13.82% versus -5.4±12.14%), dyspnoea scores (-0.4±1.27 versus -0.8±0.73 units) and St George's Respiratory Questionnaire total domain scores (-4.9±8.3 U versus -12.2±12.38 units) were better with HD than with LD therapy. BioLVR therapy with 20 mL per site at eight subsegmental sites may be a safe and effective therapy in patients with advanced homogeneous emphysema. Copyright
Original language | English |
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Pages (from-to) | 20-27 |
Number of pages | 8 |
Journal | European Respiratory Journal |
Volume | 36 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2010 |
Externally published | Yes |
Keywords
- Bronchoscopic lung volume reduction
- Emphysema therapy
- Homogeneous emphysema
- Interventional pulmonology
- Lung volume reduction surgery
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine