Biology and therapy of fibromyalgia: Genetic aspects of fibromyalgia syndrome

Dan Buskila, Piercarlo Sarzi-Puttini

    Research output: Contribution to journalReview articlepeer-review

    108 Scopus citations

    Abstract

    Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems play a role in the etiology of FMS. These polymorphisms are not specific for FMS and are associated with other functional somatic disorders and depression. Future genetic studies in the field of FMS and related conditions should be conducted in larger cohorts of patients and ethnically matched control groups.

    Original languageEnglish
    Article number218
    JournalArthritis Research and Therapy
    Volume8
    Issue number5
    DOIs
    StatePublished - 1 Oct 2006

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