Biology of the fibroblast growth factor gene family

D. Benharroch, D. Birnbaum

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

The biology of the fibroblast growth factor (FGF) gene family is reviewed. The structure, expression and known and putative functions of the seven members of this family characterized to date are discussed. These genes include: acidic and basic FGF, the INT.2 and HST proto-oncogenes and the recently characterized FGF.5, FGF.6 and KGF genes. These genes play a role in various processes such as cell proliferation, angiogenesis and embryogenesis, and possibly carcinogenesis.

Original languageEnglish
Pages (from-to)212-219
Number of pages8
JournalIsrael Journal of Medical Sciences
Volume26
Issue number4
StatePublished - 1 Jan 1990

Keywords

  • amplification
  • angiogenesis
  • growth factors
  • mesoderm induction
  • oncogenes
  • transformation

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