TY - JOUR
T1 - Biomarkers in fibromyalgia
AU - Ablin, Jacob N.
AU - Buskila, Dan
AU - Clauw, Daniel J.
N1 - Funding Information:
Dr. Daniel J. Clauw is a consultant for Cypress Bioscience, Eli Lilly and Co., Pfizer, Inc., and Wyeth Pharmaceuticals. He has received research grants from Forest Laboratories.
PY - 2009/10/9
Y1 - 2009/10/9
N2 - Fibromyalgia is a common pain syndrome characterized by widespread pain, tenderness, and a number of other somatic symptoms and syndromes. Although there was original skepticism that any objective abnormalities would be identified in these individuals, at present there are many that have been reproducibly identified, and most point to dysregulation of central nervous system function as a key underlying pathogenic mechanism in this and related illnesses. This article reviews several objective abnormalities or measures that have been identified or used in fibromyalgia, and indicates which of these may be most promising to eventually use as biomarkers to follow the response to treatment or progress of disease over time.
AB - Fibromyalgia is a common pain syndrome characterized by widespread pain, tenderness, and a number of other somatic symptoms and syndromes. Although there was original skepticism that any objective abnormalities would be identified in these individuals, at present there are many that have been reproducibly identified, and most point to dysregulation of central nervous system function as a key underlying pathogenic mechanism in this and related illnesses. This article reviews several objective abnormalities or measures that have been identified or used in fibromyalgia, and indicates which of these may be most promising to eventually use as biomarkers to follow the response to treatment or progress of disease over time.
UR - https://www.scopus.com/pages/publications/70349633267
U2 - 10.1007/s11916-009-0056-3
DO - 10.1007/s11916-009-0056-3
M3 - Review article
C2 - 19728959
AN - SCOPUS:70349633267
SN - 1531-3433
VL - 13
SP - 343
EP - 349
JO - Current Pain and Headache Reports
JF - Current Pain and Headache Reports
IS - 5
ER -