Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation

Donata Iandolo; Jonathan Sheard; Galit Karavitas Levy; Charalampos Pitsalidis; Ellasia Tan; Anthony Dennis; Ji Seon Kim; Athina E. Markaki; Darius Widera; Róisín M. Owens

doi:10.1557/mrc.2020.10

Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation

Donata Iandolo, Jonathan Sheard, Galit Karavitas Levy, Charalampos Pitsalidis, Ellasia Tan, Anthony Dennis, Ji Seon Kim, Athina E. Markaki, Darius Widera, Róisín M. Owens

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds' electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.

Original language	English
Pages (from-to)	179-187
Number of pages	9
Journal	MRS Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1557/mrc.2020.10
State	Published - 1 Mar 2020
Externally published	Yes

ASJC Scopus subject areas

General Materials Science

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title = "Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation",

abstract = "Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds' electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.",

author = "Donata Iandolo and Jonathan Sheard and {Karavitas Levy}, Galit and Charalampos Pitsalidis and Ellasia Tan and Anthony Dennis and Kim, {Ji Seon} and Markaki, {Athina E.} and Darius Widera and Owens, {R{\'o}is{\'i}n M.}",

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AU - Iandolo, Donata

AU - Sheard, Jonathan

AU - Karavitas Levy, Galit

AU - Pitsalidis, Charalampos

AU - Tan, Ellasia

AU - Dennis, Anthony

AU - Kim, Ji Seon

AU - Markaki, Athina E.

AU - Widera, Darius

AU - Owens, Róisín M.

PY - 2020/3/1

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N2 - Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds' electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.

AB - Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds' electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.

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Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation

Abstract

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