Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation

Donata Iandolo, Jonathan Sheard, Galit Karavitas Levy, Charalampos Pitsalidis, Ellasia Tan, Anthony Dennis, Ji Seon Kim, Athina E. Markaki, Darius Widera, Róisín M. Owens

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds' electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.

Original languageEnglish
Pages (from-to)179-187
Number of pages9
JournalMRS Communications
Volume10
Issue number1
DOIs
StatePublished - 1 Mar 2020
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science (all)

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