Biomimetic supramolecular assemblies for studying membrane interactions in vitro and in vivo

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

We designed a novel biomimetic sensor, composed of conjugated polydiacetylene (PDA) matrix embedded within lipid vesicles. The system is capable of detecting various compounds occurring within lipid membranes through rapid colorimetric as well as fluorescent transitions. The colorimetric response of the sensor is correlated to the extent of compound-membrane binding and permeation and quantified binding sensitivity to lipid composition. We describe a new disease diagnostic approach, denoted ‘‘reactomics’’,
based upon reactions between blood sera and an array of vesicles comprising different lipids and polydiacetylene (PDA), a chromatic polymer. We show that reactions between sera and such a lipid/PDA vesicle array produce
chromatic patterns which depend both upon the sera composition as well as the specific lipid constituents within the vesicles. Through attachment of chromatic polydiacetylene (PDA) nanopatches onto the plasma membrane, real-time
visualization of surface processes in living cells is possible
Original languageEnglish
Article numberP-057
Pages (from-to)51-51
JournalEuropean Biophysics Journal
Volume40
StatePublished - Aug 2011

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