Keyphrases
Elimination Half-life
100%
N-terminal Domain
100%
Matrix Metalloproteinase Inhibitors
100%
Bioorthogonal
100%
TIMP-2
100%
PEGylation
100%
MMP14
35%
PEGylated
21%
Matrix Metalloproteinases
14%
Tissue Inhibitor of metalloproteinase-1 (TIMP-1)
14%
Noncanonical Amino Acids
14%
Mono-PEGylation
14%
PEGylated Proteins
14%
Biological Processes
7%
Inhibitory Activity
7%
Modified Proteins
7%
Fold Increase
7%
Active Sites
7%
Conjugation
7%
Biological Activity
7%
Pharmacokinetic Profile
7%
Circulation Half-life
7%
Proteolysis
7%
Potential Therapeutics
7%
Natural Inhibitors
7%
Lysine
7%
Cysteine Residues
7%
Extracellular Matrix Protein 1 (ECM1)
7%
Binding Interface
7%
Zn2+
7%
Cancer Development
7%
Lysine Residue
7%
Propargyl
7%
Inhibition Studies
7%
Azides
7%
Serum Stability
7%
In Vivo Pharmacokinetics
7%
Life-limiting
7%
Click Chemistry Reaction
7%
Site-specific PEGylation
7%
Pharmacology, Toxicology and Pharmaceutical Science
Elimination
100%
Matrix Metalloproteinase
100%
PEGylation
100%
Matrix Metalloproteinase 14
83%
Amino Acid
33%
Lysine
33%
Pharmacokinetics
33%
Tissue Inhibitor of Metalloproteinase
33%
Mouse
16%
Disease
16%
Polyethylene Glycol
16%
Malignant Neoplasm
16%
Biological Activity
16%
Cysteine
16%
Azide
16%
Zinc Ion
16%
Immunology and Microbiology
Amino Terminal Sequence
100%
PEGylation
100%
Elimination Half-Life
100%
Pharmacokinetics
18%
Mouse
9%
Extracellular Matrix
9%
Protein Degradation
9%
Biological Activity
9%
Biological Phenomena and Functions Concerning the Entire Organism
9%
Click Chemistry
9%