Bipolar disorder

Nirit Kara, Haim Einat

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

The paucity of good and valid animal models for bipolar disorder (BPD) is one factor that is repeatedly mentioned as a bottleneck in the research into the biology of the disease and the efforts to develop better and more eicacious treatments (Einat et al., 2007a; Large et al., 2008; Nestler et al., 2002; Tecott and Nestler, 2004). Bipolar disorder is a severe psychiatric disorder afecting between 1% and 4% of the world’s population (Angst et al., 2003; Merikangas et al., 2007). Bipolar disorder is recognized for its pervasiveness and its significant morbidity, comorbidity with other psychiatric and non-psychiatric diseases, as well as its high inancial burden on society (Begley et al., 2001; Calabrese et al., 2003; Goodwin and Jamison, 1990; Kupfer, 2005; Michaud et al., 2001). Similar to other psychiatric disorders, the ability to translate novel molecular findings related to BPD to the behavioral realm of a whole organism depends on the existence of appropriate animal models, but such models are not readily available.

Original languageEnglish
Title of host publicationBehavioral Genetics of the Mouse Volume II
Subtitle of host publicationGenetic Mouse Models of Neurobehavioral Disorders
PublisherCambridge University Press
Pages278-292
Number of pages15
ISBN (Electronic)9781107360556
ISBN (Print)9781107044456
DOIs
StatePublished - 1 Jan 2014

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