Abstract
The paucity of good and valid animal models for bipolar disorder (BPD) is one factor that is repeatedly mentioned as a bottleneck in the research into the biology of the disease and the efforts to develop better and more eicacious treatments (Einat et al., 2007a; Large et al., 2008; Nestler et al., 2002; Tecott and Nestler, 2004). Bipolar disorder is a severe psychiatric disorder afecting between 1% and 4% of the world’s population (Angst et al., 2003; Merikangas et al., 2007). Bipolar disorder is recognized for its pervasiveness and its significant morbidity, comorbidity with other psychiatric and non-psychiatric diseases, as well as its high inancial burden on society (Begley et al., 2001; Calabrese et al., 2003; Goodwin and Jamison, 1990; Kupfer, 2005; Michaud et al., 2001). Similar to other psychiatric disorders, the ability to translate novel molecular findings related to BPD to the behavioral realm of a whole organism depends on the existence of appropriate animal models, but such models are not readily available.
Original language | English |
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Title of host publication | Behavioral Genetics of the Mouse Volume II |
Subtitle of host publication | Genetic Mouse Models of Neurobehavioral Disorders |
Publisher | Cambridge University Press |
Pages | 278-292 |
Number of pages | 15 |
ISBN (Electronic) | 9781107360556 |
ISBN (Print) | 9781107044456 |
DOIs | |
State | Published - 1 Jan 2014 |
ASJC Scopus subject areas
- General Agricultural and Biological Sciences