TY - JOUR
T1 - Birth during the moderate weather seasons is associated with early onset of type 1 diabetes in the Mediterranean area
AU - Adar, Adi
AU - Shalitin, Shlomit
AU - Eyal, Ori
AU - Loewenthal, Neta
AU - Pinhas-Hamiel, Orit
AU - Zuckerman Levin, Nehama
AU - Dally-Gottfried, Orna
AU - Landau, Zohar
AU - Zung, Amnon
AU - Levy-Khademi, Floris
AU - Zangen, David
AU - Tenenbaum-Rakover, Yardena
AU - Rachmiel, Marianna
N1 - Publisher Copyright:
© 2020 John Wiley & Sons Ltd
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Aim: To assess the association of seasonal and perinatal parameters with early age of type 1 diabetes (T1D) onset. Methods: A cross-sectional review of all medical records of T1D patients born between the years 1990 and 2005, and diagnosed before/by the age of 10 years, from 13 university-affiliated paediatric medical centres in Israel, was performed. Data included: gender, ethnicity, seasons of birth and disease onset, birth gestational age and weight, and autoimmune diseases of the probands and their first-degree family members. Statistical analysis included the Chi-square test or Mann-Whitney test, as appropriate and multivariate regression analysis. Results: Enrolled were 1571 T1D patients at a median age of T1D onset 6.9 years (IQR 4.4,8.4); 336 of them presented before 4 years of age. The median age of this group was 2.5 years (IQR 1.7,3.2), and of the 1235 patients who presented after 4 years of age, median presentation age was 7.5 years (IQR 6.1,8.8). Multivariate regression analysis demonstrated that a more recent birth year; OR = 1.06, 95% CI 1.02-1.1, P = 0.003, and birth during the moderate weather months (September, October, March, and April) were significantly associated with younger age at T1D onset; OR = 1.68, 95% CI 1.17-2.4, P = 0.005. Conclusions: Our novel finding demonstrates the association between younger than 4 years old age at presentation and birth during moderate weather months. The results also support previous reports, that there is a slight increase in the annual incidence of T1D in the youngest age groups.
AB - Aim: To assess the association of seasonal and perinatal parameters with early age of type 1 diabetes (T1D) onset. Methods: A cross-sectional review of all medical records of T1D patients born between the years 1990 and 2005, and diagnosed before/by the age of 10 years, from 13 university-affiliated paediatric medical centres in Israel, was performed. Data included: gender, ethnicity, seasons of birth and disease onset, birth gestational age and weight, and autoimmune diseases of the probands and their first-degree family members. Statistical analysis included the Chi-square test or Mann-Whitney test, as appropriate and multivariate regression analysis. Results: Enrolled were 1571 T1D patients at a median age of T1D onset 6.9 years (IQR 4.4,8.4); 336 of them presented before 4 years of age. The median age of this group was 2.5 years (IQR 1.7,3.2), and of the 1235 patients who presented after 4 years of age, median presentation age was 7.5 years (IQR 6.1,8.8). Multivariate regression analysis demonstrated that a more recent birth year; OR = 1.06, 95% CI 1.02-1.1, P = 0.003, and birth during the moderate weather months (September, October, March, and April) were significantly associated with younger age at T1D onset; OR = 1.68, 95% CI 1.17-2.4, P = 0.005. Conclusions: Our novel finding demonstrates the association between younger than 4 years old age at presentation and birth during moderate weather months. The results also support previous reports, that there is a slight increase in the annual incidence of T1D in the youngest age groups.
KW - birth season
KW - early onset
KW - type 1 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85083674625&partnerID=8YFLogxK
U2 - 10.1002/dmrr.3318
DO - 10.1002/dmrr.3318
M3 - Article
C2 - 32270907
AN - SCOPUS:85083674625
SN - 1520-7552
VL - 36
JO - Diabetes/Metabolism Research and Reviews
JF - Diabetes/Metabolism Research and Reviews
IS - 7
M1 - e3318
ER -