TY - JOUR
T1 - Birth month as a risk factor for the diagnosis of celiac disease later in life
T2 - A Population-based Study
AU - Assa, Amit
AU - Waisbourd-Zinman, Orith
AU - Daher, Saleh
AU - Shamir, Raanan
N1 - Publisher Copyright:
Copyright © 2018 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Various perinatal factors have been implicated in association with the risk of developing celiac disease (CD) in genetically susceptible individuals. Our aim was to investigate the association of month and season of birth with the development of CD later in life in a large National cohort in Israel. Data were retrieved from a National database of more than 2 million Israeli Jewish adolescents born between 1971 and 1998. Overall, 10,566 CD cases out of 2,001,353 subjects (0.53%) were identified and analyzed. CD risk was significantly higher for subjects born in May (odds ratio [OR] 1.07, P ¼ 0.04) and June (OR 1.09, P ¼ 0.008). Birth during the winter season (December to February) showed a marginal significance toward reduced risk (OR 0.97, P ¼ 0.05). In conclusion, children born in May and June are at increased risk for CD. This increased risk provides further evidence that perinatal environmental factors increase the risk of developing CD.
AB - Various perinatal factors have been implicated in association with the risk of developing celiac disease (CD) in genetically susceptible individuals. Our aim was to investigate the association of month and season of birth with the development of CD later in life in a large National cohort in Israel. Data were retrieved from a National database of more than 2 million Israeli Jewish adolescents born between 1971 and 1998. Overall, 10,566 CD cases out of 2,001,353 subjects (0.53%) were identified and analyzed. CD risk was significantly higher for subjects born in May (odds ratio [OR] 1.07, P ¼ 0.04) and June (OR 1.09, P ¼ 0.008). Birth during the winter season (December to February) showed a marginal significance toward reduced risk (OR 0.97, P ¼ 0.05). In conclusion, children born in May and June are at increased risk for CD. This increased risk provides further evidence that perinatal environmental factors increase the risk of developing CD.
KW - Children
KW - Pediatric
KW - Perinatal
KW - Seasonality
UR - http://www.scopus.com/inward/record.url?scp=85056471524&partnerID=8YFLogxK
U2 - 10.1097/MPG.0000000000002001
DO - 10.1097/MPG.0000000000002001
M3 - Article
C2 - 29642117
AN - SCOPUS:85056471524
SN - 0277-2116
VL - 67
SP - 367
EP - 370
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 3
ER -