TY - JOUR
T1 - Bivalirudin for anticoagulation in mechanical aortic valve replacement and heparin-induced thrombocytopenia
AU - Klein, Moti
AU - Tomer, Aaron
AU - Swartz, Andre
AU - Koyffman, Leonid
AU - Weksler, Natan
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Heparin-induced thrombocytopenia (HIT) is a potentially serious syndrome. Since there are some alternatives to treatment with heparin in patients who develop HIT, the decision as to which to use should be based on renal and hepatic function, drug availability and the available monitoring resources. We report a patient who received heparin for mechanical aortic valve replacement. Her clinical course was complicated by HIT, which was treated initially by danaparoid. The syndrome progressed with new thrombotic complications, and eventually was treated successfully by bivalirudin (Angiomax; Medison Pharma Ltd, Petach Tikva, Israel) for 9 days. We propose that treatment with bivalirudin for several days is a safe and effective alternative to heparin therapy in patients who develop HIT.
AB - Heparin-induced thrombocytopenia (HIT) is a potentially serious syndrome. Since there are some alternatives to treatment with heparin in patients who develop HIT, the decision as to which to use should be based on renal and hepatic function, drug availability and the available monitoring resources. We report a patient who received heparin for mechanical aortic valve replacement. Her clinical course was complicated by HIT, which was treated initially by danaparoid. The syndrome progressed with new thrombotic complications, and eventually was treated successfully by bivalirudin (Angiomax; Medison Pharma Ltd, Petach Tikva, Israel) for 9 days. We propose that treatment with bivalirudin for several days is a safe and effective alternative to heparin therapy in patients who develop HIT.
KW - Bivalirudin
KW - Heparin-induced thrombocytopenia
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=33646806828&partnerID=8YFLogxK
U2 - 10.1097/01.mbc.0000224857.73119.97
DO - 10.1097/01.mbc.0000224857.73119.97
M3 - Article
C2 - 16651880
AN - SCOPUS:33646806828
SN - 0957-5235
VL - 17
SP - 331
EP - 333
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
IS - 4
ER -