Blood-Brain Barrier Imaging in Human Neuropathologies

Ronel Veksler, Ilan Shelef, Alon Friedman

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

The blood-brain barrier (BBB) is essential for normal function of the brain, and its role in many brain pathologies has been the focus of numerous studies during the last decades. Dysfunction of the BBB is not only being shown in numerous brain diseases, but animal studies have indicated that it plays a direct key role in the genesis of neurovascular dysfunction and associated neurodegeneration. As such evidence accumulates, the need for robust and clinically applicable methods for minimally invasive assessment of BBB integrity is becoming urgent. This review provides an introduction to BBB imaging methods in the clinical scenario. First, imaging modalities are reviewed, with a focus on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). We then proceed to review image analysis methods, including quantitative and semi-quantitative methods. The advantages and limitations of each approach are discussed, and future directions and questions are highlighted.

Original languageEnglish
Pages (from-to)646-652
Number of pages7
JournalArchives of Medical Research
Volume45
Issue number8
DOIs
StatePublished - 1 Nov 2014

Keywords

  • Blood-brain barrier
  • Magnetic resonance
  • Neuropathologies
  • Neurovascular

ASJC Scopus subject areas

  • General Medicine

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