Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons

Hadas Tilleman, Vicky Hakim, Orna Novikov, Keren Liser, Limor Nashelsky, Michela Di Salvio, Mark Krauthammer, Oren Scheffner, Ido Maor, Oded Mayseless, Inbal Meir, Galya Kayam, Dalit Sela-Donenfeld, Antonio Simeone, Claude Brodski

    Research output: Contribution to journalArticlepeer-review

    17 Scopus citations


    The locus coeruleus (LC) which is the major noradrenergic nucleus in the brain develops under the influence of Bmps secreted by the roof plate and Fgf8 emitted from the mid-hindbrain organizer. We studied the development of the LC in different Bmp mouse mutants and report the absence of this nucleus in Bmp5-/-;Bmp7-/- double knockouts. Notably, genes marking organizers and neuronal populations adjacent to the LC precursor field are unperturbed in Bmp5-/-;Bmp7-/- animals. In addition, we found that in En1+/Otx2 mutants in which the caudal Otx2 expression domain and thereby the mid-hindbrain organizer are shifted caudally, LC neurons are concomitantly reduced along with Bmp5/7. Complementing these results, Otx1-/-;Otx2+/- mutants, in which the mid-hinbrain organizer is shifted rostrally, show a rostrally extended Bmp5 expression area and an increase in LC neurons. Taken together, our data indicate that LC development requires either Bmp5 or Bmp7, and one is able to compensate for the loss of the other. In addition, we conclude that the position of the mid-hindbrain organizer determines the size of the LC and propose that Bmp5/7 play an important role in mediating this organizer function.

    Original languageEnglish
    Pages (from-to)1-11
    Number of pages11
    JournalMolecular and Cellular Neuroscience
    Issue number1
    StatePublished - 1 Sep 2010


    • Bmp5
    • Bmp7
    • Bone morphogenetic proteins
    • Development
    • Hindbrain
    • Isthmic organizer
    • Locus coeruleus
    • Mid-hindbrain organizer
    • Noradrenaline
    • Otx2

    ASJC Scopus subject areas

    • Molecular Biology
    • Cellular and Molecular Neuroscience
    • Cell Biology


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