Bone Endosteal Mimics Regulates Breast Cancer Development and Phenotype

Noa Ben Ghedalia Peled, Dane K. Hoffman, Livnat Barsky, Noy S. Zer, Katya Amar, Hanna Rapaport, Levi A. Gheber, Xiang H.F. Zhang, Razi Vago

Research output: Contribution to journalArticlepeer-review

Abstract

Bone is a frequent site for metastatic development in various cancer types, including breast cancer, with a grim prognosis due to the distinct bone environment. Despite considerable advances, our understanding of the underlying processes leading to bone metastasis progression remains elusive. Here, we applied a bioactive three-dimensional (3D) model capable of mimicking the endosteal bone microenvironment. MDA-MB-231 and MCF7 breast cancer cells were cultured on the scaffolds, and their behaviors and the effects of the biomaterial on the cells were examined over time. We demonstrated that close interactions between the cells and the biomaterial affect their proliferation rates and the expression of c-Myc, cyclin D, and KI67, leading to cell cycle arrest. Moreover, invasion assays revealed increased invasiveness within this microenvironment. Our findings suggest a dual role for endosteal mimicking signals, influencing cell fate and potentially acting as a double-edged sword, shuttling between cell cycle arrest and more active, aggressive states.

Original languageEnglish
Pages (from-to)2338-2347
Number of pages10
JournalBiomacromolecules
Volume25
Issue number4
DOIs
StatePublished - 8 Apr 2024

ASJC Scopus subject areas

  • Bioengineering
  • Materials Chemistry
  • Polymers and Plastics
  • Biomaterials

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